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This volume represents the proceedings of the 24th Mos bach
Colloquium on "Regulation of Transcription and Trans lation in
Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany,
under the auspices of the Gesellschaft fiir Biologische Chemie. To
the three of us (H. KERSTEN, P. KARLSON and myself) who were
commissioned with the invitation of speakers, it was a difficult
decision as to whether we should attempt to cover with some twenty
contributions as many aspects of this broad topic as possible, or
to sacrifice the intellectually perhaps more pleasing but more
specula tive concepts and to concentrate on a few aspects of gene
expression in reasonable detail. We unanimously decided on the
latter course, leaving such important and timely topics as for
example, hormone action, cyclic AMP and reverse transcription to
the proceedings of other symposia, and con centrating on the four
questions which are most basic to an understanding of the
mechanisms of transcription and trans lation and for which
fragmentary but nonetheless reliable experimental results have
become available within the last few years. These are the structure
of chromatin, the syn thesis of messenger RNA, the structure of the
active ribo some, and the role of initiation factors in protein
synthesis.
The 1st International Workshop in the Molecular and Cell Biology of
Autoan tibodies and Autoimmunity is convened at a time when
recombinant DNA tech niques have yielded the first set of data
providing initial glimpses of epitopes recognized by
autoantibodies. It's aim is to bring together cell and molecular
biologists with clinical scien tists to discuss the broad spectrum
of questions concerning the relationship be tween clinical symptoms
and the specificity of autoantibodies. The response to the call for
abstracts was overwhelming: Nearly one hundred abstracts were
received from many laboratories throughout the world. The topics
covered by them are representative of the current research efforts
going on to study cause and effect of autoimmune diseases. One of
the aims of this workshop is to bring the rapid advances in the
elucidation of the molecular structure of auto antigens to the
attention of immunologists, cell biologists and clinical scien
tists and also to make molecular biologists bei6ple aware of the
difficulties lying ahead in trying to understand the cellular and
molecular basis of rheumatic dis eases. The organisers wish to
thank NIH, BMFT and the Japanese Educational Foundation for
financial support, the Heidelberg Academy for the Humanities and
Sciences for hosting the workshop, Springer Verlag for their
generous cooperation in including late abstracts in this volume,
and, last not least, Ms. Simone KRAMBS for untiring secretarial
help."
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