This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

The fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. A strong insight in driving a chemical reaction is crucial for a deeper understanding of new potential technologies. New procedures for warranty of safety and green principles are discussed. Vol. 1: Fundamentals.

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

El Filioque es una de las cuestiones mas largas y complejas de la historia del dogma cristiano. Se cuenta todavia entre las causas de la division entre catolicos y ortodoxos. En 1995, a peticion de Juan Pablo II, el Pontificio Consejo para la promocion de la Unidad de los Cristianos publico un breve texto que expresa la comprension catolica del problema. Entre sus diversas implicaciones, el documento, conocido como Clarificacion romana, se centra en los aspectos dogmaticos, que expone a partir de una amplia base de referencias patristicas. El presente estudio analiza la Clarificacion en dos partes. La primera presenta los precedentes historicos y magisteriales del texto, su genesis y sus fuentes, y ofrece una sintesis de las reacciones ecumenicas que siguieron a su publicacion. Como via para un entendimiento, la segunda parte del texto propone una consideracion detenida de las fuentes patristicas, orientales y occidentales. En ella se presentan los principales pasajes sobre el origen del Espiritu Santo y su relacion con el Hijo, contextualizados en el pensamiento trinitario de cada Padre. En funcion de el se valora el uso que ha realizado la Clarificacion de sus fuentes.