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This book covers our current understanding of the role of
mesenchymal stem cells (MSCs) and other mesenchymal progenitors in
skeletal regeneration, encompassing bone, cartilage and whole joint
regeneration. The expansion reflects developments in the field to
include data on the use of MSCs in drug development, growth
factors, scaffolds and biomechanical manipulations for skeletal
trauma and diseases, including osteoporosis and arthritis.
Written for an audience of clinicians and young researchers who
are exposed to MSCs in their work, this work summarizes recent
findings pertaining to the definition and characterization of MSCs
in skeletal tissues and discusses the mechanisms of their actions
in regeneration of bone in vivo. The authors describe recent
findings pertaining to the efficacy of MSC therapies in animal
models and in human clinical trials and bring together literature
showing that the ways MSCs are extracted, expanded and implanted
can considerably affect bone formation outcomes. Finally, it
presents the latest knowledge on the nature of native MSCs in
skeletal tissues, which provide a platform for novel in situ tissue
regeneration approaches for systemic bone disease such as
osteoporosis.
Focuses specifically on the use of stem cells in skeletal tissue
generation for a broad audience of stem cell, cancer, and bone
biologists, orthopedists, oncologists, and regenerative medicine
specialistsProvides a short historical detour and foundational
information on founding concepts, discoveries and personalities in
MSC researchAssists a new generation of scientists and clinicians
in digesting the multitude of journal articles on the topic by
providing easily-absorbed and condensed foundational context"
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