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DNA replication is a key event in the cell cycle. Although our
knowledge is far from complete and many elusive regulatory
mechanisms still remain beyondour grasp, many enzymes and a
multiplicity of biochemical mechanisms involved have been
discovered. Recent findings in E. coli have confirmed and yet
surpassed the original hypothesis of F. Jacob. In yeast and higher
eucaryotes, the apparent redundancy in putative origins and
initiators has made an estimation of the importance of each
identified element difficult to access. In spite of well
established methodologies - which are also described in the book -
the origin identification in mammalian chromosomes is still a
controversial subject. On the other hand, considerable advances
have been made in our understanding of virus DNA replication and
this continues to deepen and broaden our understanding of the
controls of cellular DNA replication.
Provided here is an easily accessible introduction to the
mechanisms of DNA replication, regulation and the biochemistry of
cell cycle control. An overview of this rapidly developing field is
presented to orient the reader, followed by a series of
contributions by leading researchers summarizing recent results on
selected topics, such as protein phosporylation, tumor suppressor
genes, and signal transduction in prokaryotic and eucaryotic
systems. The reader will gain an overview of our current
understanding of DNA replication and the cell cycle, and a
selection of useful recent references for further reading.
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