Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. Content Level Research

Weixing, or “surname guessing,� was a highly organized lottery practice in China wherein money was bet on the surnames of which candidates would pass the civil and military examinations. For centuries, up until 1905, the examination system was the primary means by which the Chinese state selected new officials from all over the empire and a way for commoners to climb the social ladder. How was betting on the examinations possible and why did it matter? Opening with a weixing-related examination scandal in 1885, En Li reconstructs the inner mechanisms of weixing and other lottery games in the southern province of Guangdong. By placing the history of the lottery in a larger context, the author traces a series of institutional revenue innovations surrounding lottery regulation from the 1850s to the early 1900s, and depicts an expansive community created by the lottery with cultural and informational channels stretching among Guangdong, Southeast Asia, and North America. This book sheds light on a new reality that emerged during the final decades of China’s last imperial dynasty, with a nuanced understanding of competitions, strategic thinking by lottery players and public officials seeking to maximize revenues, and a global network of players.

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Weixing, or “surname guessing,� was a highly organized lottery practice in China wherein money was bet on the surnames of which candidates would pass the civil and military examinations. For centuries, up until 1905, the examination system was the primary means by which the Chinese state selected new officials from all over the empire and a way for commoners to climb the social ladder. How was betting on the examinations possible and why did it matter? Opening with a weixing-related examination scandal in 1885, En Li reconstructs the inner mechanisms of weixing and other lottery games in the southern province of Guangdong. By placing the history of the lottery in a larger context, the author traces a series of institutional revenue innovations surrounding lottery regulation from the 1850s to the early 1900s, and depicts an expansive community created by the lottery with cultural and informational channels stretching among Guangdong, Southeast Asia, and North America. This book sheds light on a new reality that emerged during the final decades of China’s last imperial dynasty, with a nuanced understanding of competitions, strategic thinking by lottery players and public officials seeking to maximize revenues, and a global network of players.