Feature-length animated adventure following Scooby-Doo (voice of Frank Welker) and the Mystery, Inc. gang. Shaggy (Matthew Lillard), Fred (also Welker), Daphne (Grey DeLisle), Velma (Mindy Cohn) and Scooby-Doo win places on board a spaceship and head out on their journey along with various characters including billionaire Sly Baron (Malcolm McDowell) and astronaut Shannon Lucas (Jennifer Hale). While they are in space they encounter an alien who wreaks havoc with their vessel and they are forced to land on the moon. Can the gang catch the alien and get everyone safely back to Earth?