This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes - such as oncogenes, proto-oncogenes, or tumor suppressor genes - in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

The legal sector is facing a period of major metamorphosis - disruptors are making waves in the structuring, process, and service-delivery models, and client's needs are becoming more demanding and value-focused. As the landscape of law transforms many firms will be left facing a situation of, in John Alber's words, change or die. How will law firms keep up with upcoming rapid and volatile changes to the legal sector, and what form will they take after the transformation? What will the law firm of the future be like, and what can firms do today to ensure they are properly future proofed? Lawscape 2025: Defining the law firm of tomorrow is an exploration of the biggest innovations, strategies, and disruptors that are set to change the face of legal practice. Featuring leading industry experts weighing in on topics such as future firm structures and leadership strategies, revolutionised compensation measures, and the growing prevalence of big data, analytics, and artificial intelligence, this title will serve as a trusty manual on surviving the changing landscape of the legal world.

Disrupting an insurgent's access to sanctuary and safe-haven is a critical aspect of operational planning for counterinsurgent forces. By denying an insurgent's access to safe-havens early in the conflict, the counterinsurgent will gain a marked advantage over the initially weaker force. Only through a deep understanding of how the insurgent is using international, tribal, or cultural borders to evade the counterinsurgent force can the counterinsurgent disrupt the insurgent operations. In order to accomplish this, the counterinsurgent must understand the physical terrain and cultural demographics, nest border operations into the overarching strategy, and employ security forces to reinforce success. Through the examination of the British experience in the North-West Frontier, 1849-1947 and the counterinsurgent efforts in the Sultanate of Oman's Dhofar Rebellion, 1962-1975, one can develop techniques for applying border control operations to disrupt insurgent safe-havens. Border control efforts are not the decisive effort within a counterinsurgency, but they are critical to defeating the insurgent's ability to maintain their ability to conduct operations.

Disrupting an insurgent's access to sanctuary and safe-haven is a critical aspect of operational planning for counterinsurgent forces. By denying an inurgent's access to safe havens early in the conflict, the counterinsurgent will gain a marked advantage over the initially weaker force. Only through a deep understanding of how the insurgent is using international, tribal, or cultural borders to evade the counterinsurgent force can the counterinsurgent disrupt the insurgent operations. In order to accomplish this, the counterinsurgent must understand the physical terrain and cultural demographics, nest border operations into the overarching strategy, and employ security forces to reinforce success. Through the examination of the British experience in the North-West Frontier, 1849-1947 and the counterinsurgent efforts in the Sultanate of Oman's Dhofar Rebellion, 1962-1975, one can develop techniques for applying border control operations to disrupt insurgent safe-havens. Border control efforts are not the decisive effort within a counterinsurgency, but they are critical to defeating the insurgent's ability to maintain their ability to conduct operations.