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vi as did non-appreciation that % values for bought-in solutions
(notably ammonia) may be on a weight basis, not made evident by the
manufacturer. Notwithstanding the shortcomings or lateness of some
texts, authors are thanked for compiling them amidst other
pressures. Elsevier and the American Chemical Society are also
thanked, for Figures now reproduced with source acknowledgement.
This Editor has generally respected authors' phrasing, whilst
shuddering when the term 'incubate' is encountered in a 0 Degrees
context. He remains a 'diehard' in certain respects, notably in
favouring 'M' rather than 'mol/I', and a wt./ml basis for drug
concentrations in test samples; he regards 'mmol/l' as a fatuous
fashion. Concerning infelicitous abbreviations, a distinction is
made between electron capture (detector context; 'ECD') and
electrochemical ('EC', never 'ECD'); the hallowed GC term 'FID'
means free induction decay to NMR practi tione:ts, who may pardon
the term 'Fid' as introduced editorially. The convention for ,0C'
throughout the book is '0'. Undefined but well-known abbreviations
include GC, HPLC and TLC. MS (mass spectrometry), NPD
(nitrogen-phosphorus detector), tr (retention time) and RIA
(radioimmunoassay) are usually defined in the article concerned, as
are the HPLC modes NP (normal-/straight phase) and RP
(reversed-phase; C-lS and ODS are synonymous), and i.s.
Jane Austen's fiction is itself philosophy, a fact to which Stanley
Cavell attested when he honored his philosophical teacher, J. L.
Austin, through homage to her and her work. Engaging equally in
criticism and in philosophy, Jane Austen and Other Minds
demonstrates the standing of Austen's fiction as a philosophical
investigation, both in its own right and as a resource to ordinary
language philosophy in the twentieth and twenty-first centuries.
Eric Reid Lindstrom addresses a long-standing shortcoming of Austen
scholarship by locating in her fiction a linguistic phenomenology
available to the novelistic everyday but not afforded her in
intellectual history. He simultaneously advances recognition and
understanding of J. L. Austin and Stanley Cavell, and of ordinary
language philosophy, within Austen scholarship and the broader
field of contemporary literary studies. This book argues
compellingly for Cavell's choice of Austen as a means to pursue
'passionate exchange,' reimagining her common association with
restriction and confinement.
vi as did non-appreciation that % values for bought-in solutions
(notably ammonia) may be on a weight basis, not made evident by the
manufacturer. Notwithstanding the shortcomings or lateness of some
texts, authors are thanked for compiling them amidst other
pressures. Elsevier and the American Chemical Society are also
thanked, for Figures now reproduced with source acknowledgement.
This Editor has generally respected authors' phrasing, whilst
shuddering when the term 'incubate' is encountered in a 0 Degrees
context. He remains a 'diehard' in certain respects, notably in
favouring 'M' rather than 'mol/I', and a wt./ml basis for drug
concentrations in test samples; he regards 'mmol/l' as a fatuous
fashion. Concerning infelicitous abbreviations, a distinction is
made between electron capture (detector context; 'ECD') and
electrochemical ('EC', never 'ECD'); the hallowed GC term 'FID'
means free induction decay to NMR practi tione:ts, who may pardon
the term 'Fid' as introduced editorially. The convention for ,0C'
throughout the book is '0'. Undefined but well-known abbreviations
include GC, HPLC and TLC. MS (mass spectrometry), NPD
(nitrogen-phosphorus detector), tr (retention time) and RIA
(radioimmunoassay) are usually defined in the article concerned, as
are the HPLC modes NP (normal-/straight phase) and RP
(reversed-phase; C-lS and ODS are synonymous), and i.s.
Prefaces tend to be platitudinous and unconducive to perusal. To
this hardened Editor, the appearance of the book represents the end
of a stamina-testing saga surpassing any past experience. Amongst
the numerous authors - a notably eminent bevy - some were angelic
and others suffered harassment to produce, amidst day-to-day
pressures, an eventual article in the cause of receptor
investigation; few took exception to the strong editing that their
material underwent. The reader of this book will be interested
rather in its aims and ba- ground.- Does it merit a n his
bookshelf? The book is not a 'Proceedings', but has
sponsored-meeting parentage. Wi th company support, notably from
BetaHED Pharmaceuti cals of Indianapolis, the 8th International
Subcellular Hethodology Forum was held in July 1982 at the
University of Surrey in Guildford. The vigorous debates, partly on
aspects such as hormonal receptors and drug targeting, then
narrowed to Neuroreceptor Hethodology at a NATO Advanced Research
Workshop, perforce set up at short notice. But 'Proceedings' are
proverbially ephemeral material reflecting an array of solo
performances, whereas this book is hopefully more like an
orchestra's performance, of classical together with new material.
Retrievability of receptor 'know-how' has been a key aim. Locations
in the text, including comments and supplementary material
(designated 'NC'), are thoroughly indexed, whilst for some aspects
a 'Retrieval Key' (p. 545) should be used. Related to receptor
methodo logy, receptor features and phenomena get due attention in
the text."
Scope of the book, and acknowledgements.- The articles are focused
on 'real problems' in body-fluid analysis, typically with a final
chromatographic separation of ~g or often ng amounts if the aim is
quantitation. The pitfalls may not be realized by a typical chemist
(cf. remarks in #A-3), but he may excel in metabolite iden
tification - which this book covers to a fair extent. Where
identity is known, and the metabolite could interfere in
therapeutic drug monitoring or in diagnosis or itself have clinical
relevance, useful guidance will come from articles that follow.
Authors have gone to much trouble, and are not to be blamed by any
reader who would have liked an introduction to chromatography or to
metabolic pathways (cf. list of conjugation reactions at end of
concluding article). Appre ciation is also expressed for permission
to reproduce published mat erial; the acknowledged sources include
1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American
Chemical Society; #A-2) and Wiley.
Acknowledgements. - Valuable support for the Forum came from the
Cancer Research Campaign, from Johnson Matthey & Co., and from
U. K. pharmaceutical companies - Beechams, Glaxo, ICI and Smith,
Kline & French. Moreover, some speakers came without full
financial coverage. The choice of presentations was guided by
Honorary Advisers including Drs. S.H. Curry (Chairman), J.A.F. de
Silva, L.E. Martin, J. Chamberlain and G.G. Skellern. Drs. Jim
Leppard and Joan Reid are thanked for Index drafting. As mentioned
in the text, some Figs. have already appeared in journals, whose
publishers (e.g. Elsevier, Dekker, Preston) are thanked: sources
include Journal of Chroma- tography, Journal of Liquid
Chromatography and Journal of Chromatographic Science, also (art.
#E-S) a Wiley book edited by M. Trimble. Abbreviations.- In
connection with HPLC ('LC' is a pet aver- sion) this Editor has
often deplored the upstart use of 'ECD'-a term hallowed by its GC
usage as in art. #F -2 later in the book. To connote
'electrochemical' the term 'EC' is now used, but 'ECD' is reserved
for the electron-capture detector. Other abbreviations which,
although well known, are generally defined in each article
concerned include NP, normal-phase [HPLC); RP, reverse(d)-phase;
i.s., internal standard; MS, mass spectrometry (EI,
electron-impact; CI, chemic,al-ionization); RIA, radioimmunoassay;
UV, ultraviolet (usually absorbance).
This is a pre-1923 historical reproduction that was curated for
quality. Quality assurance was conducted on each of these books in
an attempt to remove books with imperfections introduced by the
digitization process. Though we have made best efforts - the books
may have occasional errors that do not impede the reading
experience. We believe this work is culturally important and have
elected to bring the book back into print as part of our continuing
commitment to the preservation of printed works worldwide.
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