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Anticlastogens in Mammalian and Human Cells covers research on the
protection of chromosomes from the action of chemical mutagens by
use of natural and synthetic antimutagens, which, because of their
specific action on clastogenic damage are called anticlastogens.
Based on an introductory chapter on nature and mode of formation of
chromosome aberrations induced by chemical and also physical
mutagens, the action of anticlastogens is discussed in detail. A
definition and delineation of the term anticlastogenesis is
followed by considerations on the various possibilities of
classifying anticlastogens. Attention is paid to the action of
anticlastogens in mammalian and human cell culture systems, in vivo
data on anticlastogens are presented in great detail, as are the
actions of anticlastogens on induced sister chromatid exchanges in
various test systems. A mainly historical side-glance at the action
of anticlastogens on chromosome damage induced by ionizing
radiation is taken. The practical consequences of the findings on
anticlastogenic action are extensively discussed as aspects of
further research.
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