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While cancers of the oral cavity and oropharynx were overwhelming
found in smokers and drinkers, a dramatic shift is occurring with a
dramatic rise in the incidence of HPV-associated oropharyngeal
cancers while oral cavity cancers and HPV-negative oropharyngeal
cancers appear to be declining in incidence, reflecting the
reduction in cigarette smoking. These trends also have implications
for how Otolaryngologists prevent, diagnose, workup, treat, and
follow these patients. The focus of information in this issue is on
oral cavity and oropharyngeal cancer and the implications of the
HPV epidemic on this disease. Amongst the medical community during
this period of trying to better grasp the association of HPV with
oropharyngeal cancers, there are misconceptions and a lack of
knowledge of these important shifts which are addressed by Guest
Editors Jeffrey Myers and Erich Sturgis of the University of Texas,
MD Anderson Cancer Center. Topics include: Epidemiology- Control of
a tobacco epidemic? But emergence of a HPV epidemic?; Oral cavity
and Oropharyngeal Cancer Genomics; Why Otolaryngologists need to be
aware of Fanconi anemia; Impact on HPV on Orpharyngeal Cancer
Biology and Response to Therapy-Implications for Treatment; Oral
premalignancy- The roles of early detection and chemoprevention;
Evaluation and staging- Limitations despite technological
breakthroughs; 7) Surgical treatment innovations; Radiotherapy- The
"Particle-rs? of energy, dose, and delivery method; Systemic
Treatment- Its role before, during, and after definitive treatment;
How to maximize functional assessment/rehabilitation; Standardizing
treatment for Cancers - An approach to cancer care or crisis?;
Survivorship in Oral Cancer- Competing mortalities, morbidities,
and second malignancies.
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