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This volume on iron-sulfur proteins includes chapters that discuss
how microbes, plants, and animals synthesize these complex
prosthetic groups, and why it is important to understand the
chemistry and biogenesis of iron sulfur proteins. In addition to
their vital importance in mitochondrial respiration, numerous iron
sulfur proteins are important in maintenance of DNA integrity.
Multiple rare human diseases with different clinical presentations
are caused by mutations of genes in the iron sulfur cluster
biogenesis pathway. Understanding iron sulfur proteins is important
for understanding a rapidly expanding group of metabolic pathways
important in all kingdoms of life, and for understanding processes
ranging from nitrogen fixation to human disease.
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