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The last four decades have witnessed considerable advances in our
knowledge of the pharmacology of sleep. Both basic and clinical
pharmacology have made major contributions toward our current
understanding of the complex mechanisms of sleep and wakefulness.
In addition, these advances in our understanding of the
pharmacology of sleep have benefited the treatment of sleep
disorders and various neurologic and psychiatric conditions. This
volume is organized into three different parts. The first is a
review of the basic mechanisms of sleep and wakefulness and the
chronobiology of sleep. The second part reviews the basic
pharmacology of the various neuro transmitter systems involved in
sleep and wakefulness, while the third is clinically oriented and
focuses on the effects of a variety of drugs on sleep and
wakefulness. The initial part begins with a historical review of
the hypotheses of the mechanisms of sleep, evolving from passive to
active regulation, and concepts involving sleep-related
neurotransmitters and other sleep factors. Then regulation of sleep
and wakefulness is discussed in terms of homeostatic, circadian,
and ultradian processes. Also discussed is the fact that sleep
homeostasis is not disrupted by the administration of hypnotic
drugs. This part also reviews time-dependent properties of
pharmacologic agents in relation to endogenous biologic rhythms and
more specifically to chrono pharmacologic changes."
A review of the current state of the clinical and basic science of
the pharmacology of sleep. The information provided ranges from a
historical perspective to current concepts of sleep mechanisms,
including the interaction between pharmacology and sleep-wake
regulation and between chronopahrmacology and sleep-wake rhythms.
For the first time in one single volume, both the basic mechanisms
of sleep, and the basic and clinical aspects of the pharmacology of
sleep are dealt with in a thorough, comprehensive and authoritative
manner. The chapters, written by the foremost scientific
authorities in this field, integrate the latest information on the
basic mechanisms of drugs as they relate to their effects on sleep.
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