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Applied genetic research, genetic toxicology and mutation research
investigate the mutagenicity and cancerogenicity of chemicals and
other agents. Permanent mutation in genes and chromosomes, can be
induced by aplethora of agents, including ionizing and nonionizing
radiations, chemicals, and viruses. Among the aspects discused by
Advances in Mutagenesis Research are (1) the understanding of the
molecular mechanisms leading to mutations, and (2) the prevention
of a thoughtless introduction of mutagenic agents into the
environment. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981):
An Essay on his Life and Scientific Achievements. - Arylnitrenium
Ions and the Genotoxic Potency of Aromatic Amines and Nitro
Compounds. - Analysisof Mutagenicity and Chemical Structure in
Various Series of Related Compounds. - Formation of
8-Hydroxyguanine by Oxidative DNA Damage, its Repair and its
Mutagenic Effects. - Exploring Genetic and Non-Genetic
Relationships: The Induction of Micronuclei. - Mechanisms of
Induced Mutagenesis by Ultraviolet Light in Escherichia coli. -
Polytene Chromosomes in Mutagenesis. Three-Way Differential
Stainingof Chromosomes for the Identification of SCEs per Cell
Cycle: Fundamentals and Applications. - The Mammalian Centromere:
Centromere Separation, Kinetochore Proteins and Aneuploidy. -
Chorionic Villi Analysis. - ExploringGenetic and Non-Genetic
Relationships: The Induction of Micronuclei.
Applied genetic research, genetic toxicology and mutation research
investigate the mutagenicity and cancerogenicity of chemicals and
other agents. Permanent mutation in genes and chromosomes, can be
induced by a plethora of agents, including ionizing and nonionizing
radiations, chemicals, and viruses. Among the aspects discussed by
Advances in Mutagenesis Research are (1) the understanding of the
molecular mechanisms leading to mutations, and (2) the prevention
of a thoughtless introduction of mutagenic agents into the
environment.
In the post-genomic era, one of the most important goals for the
community of plant biologists is to take full advantage of the
knowledge generated by the Arabidopsis thaliana genome project, and
to employ state-of-the-art functional genomics techniques to assign
function to each gene. This will be achieved through a complete
understanding of what all cellular components do, and how they
interact with one another to produce a phenotype. This book
discusses the findings about the function of proteins belonging to
the Arabidopsis SABATH family, by applying a combination of
genomics tools, including genome-wide expression analysis and
gas-chromatography coupled with mass spectrometry-based metabolite
profiling. These results combined with available biochemical
information, provide a better understanding of the physiological
role of SABATH methyltransferases, further insights of secondary
plant metabolism and deeper knowledge of the consequences of
modulating the expression of SABATH methyltransferases, both at the
gene expression and metabolite levels.
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