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This title tracks the development of Justice Thurgood Marshall's
rationale and reason regarding Indian law. Drawing from Marshall's
career preceding his appointment to the Supreme Court, it is
anticipated that Marshall's views In Indian law would be consistent
with his previous role as a champion of the disenfranchised in
America.
This volume marks the end of twenty years of neurosecretion during
which there were five symposia, namely Naples (1953), Lund (1957),
Bristol (1961), Strasbourg (1966), and Kiel (1970). In comparison
with these symposia an exceptionally large number of papers were
read at this the sixth symposium, in London, and for economic
reasons it has not been possible to publish all the papers in
extenso. The editors have therefore been obliged to undertake the
unenviable work of selection, a task made all the more difficult by
the excel lence and importance of contributions of the symposium.
We felt that it was of the utmost importance at this moment in the
history of neurosecretion to present as complete a picture as
possible of the present state of the subject in relation to the
past and opportunities for the future. We have therefore given some
preference to papers with a strong review element, research papers
in areas of current importance and contributions which deal with
recently developed techniques with promise for the future. We have
more over attempted to strike some balance between the different
areas of research on neurosecretion so that the volume as a whole
may be of interest to the general reader, and that he will find in
it a reasonably coherent pattern of thought which demonstrates
neurosecretion as the final neuroendocrine pathway. We have
attempted a certain degree of uniformity of spelling, symbols,
etc."
It has been known for almost 50 years that many cells carry enzymes
that hydro- lyze extracellular ATP, and the term "ecto-ATPase" was
used first by Engelhardt 40 years ago. But until the end of the
1970's, the idea of an ATPase with its ATP hydrolyzing site on the
outside of the cell membrane was met with substantial skepticism
since it was thought that ATP was strictly intracellular.
Nevertheless, ecto-ATPase activity was dem- onstrated using a
variety of intact cells. Most ecto-ATPase(s) exhibited three common
2 characteristics: 1) activation by either Ca + or Mg2+, 2)
insensitivity to the commonly used inhibitors ofF-type, P-type, and
V-type ATPases, and 3) ability to hydrolyze nucleo- side
triphosphates and often nucleoside diphosphates as well. At the
same time, the dominant ATPase activity in many plasma membrane
preparations was shown to be dis- tinct from the ion-pump ATPases,
but had similar enzymatic properties as the ecto-AT- Pase(s). Thus
the term "E-type ATPase activity" has been proposed for ATPase
activity exhibiting these characteristics, and it is assumed that
all ecto-ATPases are E-type AT- Pases. The converse is not true,
however, since soluble E-type ATPases were shown to ex- sist in
plants, microorganisms, and the saliva of blood sucking insects.
These enzymes could be easily purified, and exhibited very high
specific activity.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
The book tracks the development of Justice Thurgood Marshall's
rationale and reason regarding Indian law. Drawing from Marshall's
career preceding his appointment to the Supreme Court, it is
anticipated that Marshall's views In Indian law would be consistent
with his previous role as a champion of the disenfranchised in
America.
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