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The pharmacokinetics of digitalis glycosides have been the subject
of extensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai.,
1977). Research on glycoside kinetics has progressed at a rapid
pace, requiring continuing reevaluation of the state of our
understanding of this problem. The present article focuses on the
effect of disease states (renal, gastrointestinal, thyroid, and
cardiac) on the absorption, distribution, and clearance of a number
of digitalis glycosides. Evidence is critically reviewed, and
interpreted with respect to possible clinical implications. A.
Renal Insufficiency I. Strophanthin Strophanthin disposition in
renal failure has been evaluated in only two studies. KRAMER et ai.
(1970) determined an elimination half-life of 14 h in normals as
com pared to 60 h in anuric patients. Similar results were reported
by BRASS and Pm LIPPS (1970) using tritiated strophanthin. They
found a half-life value of 18 h in healthy individuals as compared
to 68 h in anuric patients. The findings clearly in dicate that the
elimination half-life of strophanthin is prolonged in renal
failure."
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