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The Boerhaave Committee for postgraduate Medical Education decided
to organize a course on cancer treatment covering selected solid
tumors, in which they felt important chan ges were emerging in the
basic biologic, diagnostic and therapeutic concepts. Current
management of cancer patients is intimately dependent on precise
morphologic diagnosis, clinical staging and the proper application
of all treat ment modalities. Many prominent investigators and
clinicians of major can cer centers in the United States, Canada,
and Europe con tributed by lecturing and during the panel
discussions. This book is the tangible outcome of the productive ex
changes during the meeting held December 6-8, 1979. In ovarian
cancer the usefulness of histologic grading in determining
prognosis has become clear. The most impor tant advance for the
management of the patient is th- careful staging procedure, based
on new concepts of tumor spread coupled with treatment tailored to
the extent of disease. Survival appears to be directly related to
the extent of the tumor mass. This has resulted in description and
application of optimal cyto-reductive surgery. Radiotherapy and
chemotherapy can both effectively eradi cate small amounts of
tumor."
In 1978 the Dutch Genetic SOciety organized a symposium on the
genetic aspects of the origin of tumor cells. The objective of this
symposium was to reach an overview of the state of knowledge in a
number of quite different fields related to each other through the
genetics of the initiation of tumor cells. This monograph contains
the brought-up-to-date contributions of this symposium. Herein
discussed is the extent that characteristics of tumor cells can be
considered as a phenotype. The possible role of somatic mutation
and repair of genetic damage is studied and the analysis of genes
with oncogenic potential is pursued. Also the influence of host
factors in the response to oncogenic action is dealt with. This
volume describes in a clear and concise manner the current status
in these research areas and, it is hoped, will stimulate the
exchange of information and ideas between them. Dr. F.l. CLETON,
The Netherlands Cancer Institute, Amsterdam Dr. J.W.I.M. SIMONS,
Department of Radiation Genetics and Chemical Mutagenesis,
University of Leiden CONTRIBUTORS P. Bentvelzen Ph.D.
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (ZH),
The Nether lands. F.I. Cleton M.D. Antoni van Leeuwenhoek-Huis, The
Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The
Netherlands. P. Demant M.D. Antoni van Leeuwenhoek-Huis, The
Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The
Netherlands. A.I. van der Eb Ph.D., H. Iochemsen, I.H. Lupker, I.
Maat, H. van Ormondt, P.1. Schrier."
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