De-Sign in the Transmodern World integrates design and sign by revealing the mutual reciprocities between design and semiotics, and bridging the gap between humanities and sciences. By recognizing the global scope of semiotics and tolerating the uncertainty associated with design, human beings can go beyond absoluteness and become able to envision a desirable reality in the transmodern world. This publication examines the fusion of design and semiotics, which is at the core of evolutionary love that encourages us to go beyond what we conventionally perceive into what we are imaginatively capable of interpreting. As semiotic animals, we are capable of developing awareness, relationships, and mediation toward semiosis of an undivided wholeness in flowing movement. Human beings have unlimited "semioethical" responsibility toward each other and toward other-than-human systems. This ethical implication depends on our ability to liberate ourselves from the fallacy of absolute reality.