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In his original essay on the shaking palsy (1817) James Parkinson
remarked that the "senses and intellect were uninjured." Thus, it
was only in later years that the complexity ofparkinsonism and in
particular Parkinson's disease with dementia was recognised.
Cognitive impairment in Parkinson's disease is common and is
estimated to affect more than forty per cent of patients with
disease onset after age 65. Recent studies suggest that pathology
of Parkin son's disease now ranks second to Alzheimer's disease as
the commonest sub strate of dementia in elderly patients. The
condition is heterogeneous and there remain many complicated and
unresolved questions concerning cause, diagnosis and
classification. In an attempt to clarify these issues, scientists
and members of the European Brain Bank Network (EBBN) gathered in
London for a meeting entitled "Dementia in Parkinsonism." The
resultant monograph is testimony to the wide-ranging clinical,
morphological and biochemical aspects of this condition. We are
grateful to all contributors for expressing their expert opinions
and for being so generous with their time taken in prepa ration of
the manuscripts. The meeting was funded by the Commission of the
European Communities as part of a Biomed-l Programme. We wish to
thank Amgen Limited, Lilly Industries Limited and Roche Products
Limited for additional sponsorship. The expert secretarial
assistance of R. Nani in the pre paration of this book has been
very much appreciated. London, November 1997 S. E. Daniel F. F.
Cruz-Sanchez A. J. Lees Contents Stern, G.: The language of the
basal ganglia . . . . . . . . . . . . . . . . . . . . . ."
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