This is the conference proceedings for the 18th International Conference on Hadron Spectroscopy and Structure (HADRON2019), held in Guilin, China. It is among the most important conference series in the field of hadron spectroscopy and structure. Collecting more than 130 contributions from this conference, the book spans over the topics of meson and baryon spectroscopy, exotic hadrons, hadron production and interactions, analysis tools, QCD and hadron structure, hadrons in nuclear environment and hypernuclei. Summaries of the recent discoveries from Belle, BESIII, LHCb and other high-energy experiments, as well as recent theoretical developments in the above mentioned topics, are contained in this volume, rendering it as a valuable resource for researchers working on hadron spectroscopy and structure.