This book contains the invited and contributed papers selected for presentation at SOFSEM 2021, the 47th International Conference on Current Trends in Theory and Practice of Computer Science, which was held online during January 25-28, 2021, hosted by the Free University of Bozen-Bolzano, Italy.The 33 full and 7 short papers included in the volume were carefully reviewed and selected from 100 submissions. They were organized in topical sections on: foundations of computer science; foundations of software engineering; foundations of data science and engineering; and foundations of algorithmic computational biology. The book also contains 5 invited papers.

This book constitutes the refereed proceedings of the 46th International Conference on Current Trends in Theory and Practice of Informatics, SOFSEM 2020, held in Limassol, Cyprus, in January 2020. The 40 full papers presented together with 17 short papers and 3 invited papers were carefully reviewed and selected from 125 submissions. They presented new research results in the theory and practice of computer science in the each sub-area of SOFSEM 2020: foundations of computer science, foundations of data science and engineering, foundations of software engineering, and foundations of algorithmic computational biology.