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In spite of their relatively low prevalence, systemic vasculitides
have been the object of intensive basic and clinical investigations
over the last few years. As a consequence, important advancements
have been achieved: from updated diagnostic and classification
criteria and a more rational nomenclature to the recognition of an
expanding spectrum of clinical manifestations and potentially
devastating complications; from the recognition of the viral
etiology of conditions such as HCV-related cryoglobulinemic
vasculitis and HBV-associated polyarteritis nodosa to newly named
variable vessel vasculitis exemplified by Behcet's disease; from
single-organ vasculitis such as central nervous system vasculitis
to the more recently emerging features of the IgG4-related,
immune-mediated diseases that are showing remarkable clinical
heterogeneity. In addition, intriguing pathogenetic hypotheses are
being reported for certain chronic, relapsing vasculitides that are
improving our understanding of their biology and basic
pathophysiology. New avenues are being explored that will hopefully
allow a deeper comprehension of the relationships between certain
virus-driven vasculitides and lymphoproliferation, and possibly
lead to the identification of novel biomarkers that may be used to
single out patients at an increased risk of relapse. This explosion
of knowledge is obviously resulting in state-of-the-art,
personalized treatments of systemic vasculitides. This book is a
collection of reviews on the major vasculitides, written by
scientists and clinicians with a multi-year experience in this
field. We hope it will provide the reader with a stimulating
container of new advances in scientific knowledge and more rational
therapeutic approaches to this fascinating chapter of pathology.
In spite of their relatively low prevalence, systemic vasculitides
have been the object of intensive basic and clinical investigations
over the last few years. As a consequence, important advancements
have been achieved: from updated diagnostic and classification
criteria and a more rational nomenclature to the recognition of an
expanding spectrum of clinical manifestations and potentially
devastating complications; from the recognition of the viral
etiology of conditions such as HCV-related cryoglobulinemic
vasculitis and HBV-associated polyarteritis nodosa to newly named
variable vessel vasculitis exemplified by Behcet's disease; from
single-organ vasculitis such as central nervous system vasculitis
to the more recently emerging features of the IgG4-related,
immune-mediated diseases that are showing remarkable clinical
heterogeneity. In addition, intriguing pathogenetic hypotheses are
being reported for certain chronic, relapsing vasculitides that are
improving our understanding of their biology and basic
pathophysiology. New avenues are being explored that will hopefully
allow a deeper comprehension of the relationships between certain
virus-driven vasculitides and lymphoproliferation, and possibly
lead to the identification of novel biomarkers that may be used to
single out patients at an increased risk of relapse. This explosion
of knowledge is obviously resulting in state-of-the-art,
personalized treatments of systemic vasculitides. This book is a
collection of reviews on the major vasculitides, written by
scientists and clinicians with a multi-year experience in this
field. We hope it will provide the reader with a stimulating
container of new advances in scientific knowledge and more rational
therapeutic approaches to this fascinating chapter of pathology.
Oncogenomics: From Basic Research to Precision Medicine offers a
thorough survey of precision medicine and its diagnostic and
therapeutic applications in oncology. Gathering contributions from
leading international researchers in the field, chapters examine
recent translational advances in oncogenomic methods and
technologies, detailing novel molecular classifications of tumors
as well as diagnostic and prognostic biomarkers for various types
of cancers including pancreatic, gastrointestinal, breast,
hematological, lung, osteotropic, genitourinary, and skin cancers.
This book provides a foundation for clinical oncologists, human
geneticists, and physicians to develop new targeted cancer
treatments and incorporate genomic medicine into clinical practice,
with particular attention paid to noninvasive diagnostic techniques
such as the liquid biopsy and molecular characterization of solid
malignancies.
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