Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.
With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.
Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.
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* Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective
* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.
* Up-to-date research data
* Clear illustrations complement the text

Remarkable Discoveries! is an enthusiastic and engaging narrative that explores eighteen exciting discoveries, found in all areas of science, that have had a profound impact on modern life. Writing without technical jargon, the author relates the histories of such fascinating discoveries as electricity, DNA, microbes, plate tectonics, and x-rays, emphasizing the personalities involved, the role of serendipity, and the element of surprise and wonder that often accompanies scientific research. The intriguing vignettes related in easy-to-read prose leave the reader eager to know more about the world of science and scientists.

Remarkable Discoveries shows how scientists have made great discoveries that have pushed back the frontiers of knowledge and have changed the way we look at the world. Frank Ashall, scientist and writer, takes us on a magical mystery tour of eighteen major scientific discoveries. Electricity, X-rays, DNA fingerprinting and the Big Bang are but a few of the achievements on which the author writes. We delve into the world of the researcher and experience the excitement as each discovery is unfolded. Can we thank chance or just intelligence and hard work for the scientists' success? The personalities, the trials, the triumphs are all here. Remarkable Discoveries takes the reader on an exhilarating tour through some of the major scientific discoveries that have benefited humanity.