This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.

22 papers on control of nonlinear partial differential equations highlight the area from a broad variety of viewpoints. They comprise theoretical considerations such as optimality conditions, relaxation, or stabilizability theorems, as well as the development and evaluation of new algorithms. A significant part of the volume is devoted to applications in engineering, continuum mechanics and population biology.

Consisting of 16 refereed original contributions, this volume presents a diversified collection of recent results in control of distributed parameter systems. Topics addressed include - optimal control in fluid mechanics - numerical methods for optimal control of partial differential equations - modeling and control of shells - level set methods - mesh adaptation for parameter estimation problems - shape optimization Advanced graduate students and researchers will find the book an excellent guide to the forefront of control and estimation of distributed parameter systems.

Consisting of 16 refereed original contributions, this volume presents a diversified collection of recent results in control of distributed parameter systems. Topics addressed include - optimal control in fluid mechanics - numerical methods for optimal control of partial differential equations - modeling and control of shells - level set methods - mesh adaptation for parameter estimation problems - shape optimization Advanced graduate students and researchers will find the book an excellent guide to the forefront of control and estimation of distributed parameter systems.

This volume comprises the proceedings of the "3rd International Conference on Distributed Parameter Systems" held at the Chorherrenstift Vorau (Styria), July 6-12, 1986. The aim of the meeting was to stimulate exchange of information between scientists working in the field of distributed parameter systems. The papers included in the proceedings present recent results and most of them include a survey on the background of the problem. Main topics considered in these papers are boundary control for hyperbolic systems, linear-quadratic control problems, robustness, stabilization, visco-elastic and flexible structures, hereditary systems.

This volume comprises the proceedings of the "3rd International Conference on Distributed Parameter Systems" held at the Chorherrenstift Vorau (Styria), July 6-12, 1986. The aim of the meeting was to stimulate exchange of information between scientists working in the field of distributed parameter systems. The papers included in the proceedings present recent results and most of them include a survey on the background of the problem. Main topics considered in these papers are boundary control for hyperbolic systems, linear-quadratic control problems, robustness, stabilization, visco-elastic and flexible structures, hereditary systems.

The human cardiovascular and respiratory control systems represent an important focal point for developing physiological control theory because of the complexity of the control mechanisms involved, the interaction between cardiovascular and respiratory func--tion, and the importance of this interaction in many clinical situations. This volume brings together the range of control processes involved in the effective regulation of these systems and develops modeling themes, strategies, and key clinical applications using contemporary mathematical and control methodologies. The reader will gain an appreciation of how analytical techniques and ideas from optimal control theory, systems theory, and numerical analysis can be utilized to better understand the regulation processes in human cardiovascular and respiratory systems. Cardiovascular and Respiratory Systems uses a principle-based modeling approach and analysis of feedback control regulation to elucidate the physiological relationships. Models are arranged around specific questions or conditions, such as exercise or sleep transition, and are generally based on physiological mechanisms rather than on formal descriptions of input-output behavior. The authors ask open questions relevant to medical and clinical applications and clarify underlying themes of physiological control organization. Current problems, key issues, developing trends, and unresolved questions are highlighted.