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This book has been written in response to the many physicians and
scien tists working on the development of biological approaches to
providing therapies for many orthopaedic disorders as well as to
improving the healing of many tissues of the musculoskeletal
system. The first goal of this book is to make the language
compatible between the bench scientist and the clinician working in
orthopaedic and sports medicine in order to cover specific areas of
the orthopaedic discipline where the treatment can be improved
and/or changed by the advancements in molecular medicine.
Advancements in molecular biology, which encompass the study of the
genetic basis of disease, have produced new diagnostic methods and
drug therapies for genetic diseases and acquired disorders. The
growth in the understanding of human genetics has also led to the
initiation of many human gene therapy experiments. Although many
approved therapeutic clinical trials using this new technology have
been performed in the last ten years, the first clinical trial
using this technology in the area of orthopaedics was performed at
the University of Pittsburgh."
This issue of Clinics in Sports Medicine, guest edited by Dr.
Freddie H. Fu, will cover Controversies of the Anterolateral
Complex of the Knee. Anatomical description of the anterolateral
complex of the knee; Biomechanical proof for the existence of the
Anterolateral Ligament; Biomechanics of the anterolateral
structures of the knee; Mechanical properties of the anterolateral
structures and their clinical implications; Extra articular
tenodesis in combination with ACL reconstruction; The role of an
extra-articular reconstructive surgery in primary ACL
reconstructions; The role of an extra-articular tenodesis in
revision ACL reconstruction; The effect of an extra-articular
tenodesis on the contact pressure in the lateral compartment of the
knee; and The state of the evidence in ALL research, among others.
The Adult ACL world is constantly changing and is in need of
continual updates; approximately 60,000-75,000 ACL reconstructions
are performed annually in the United States. Dr. Freddie Fu just
held a world-wide symposium on this topic and is considered the
expert. In the Clinics survey sent in the fall of 2010, survey
takers were most interested in seeing an issue on ACL repair and
injury prevention.
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