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Osteoarthritis (OA), the most common form of arthritis, is
generally characterized by a slowly progressive degeneration of
articular cartilage, particularly in the weight-bearing joints. It
has a stronger prevalence in women, and its incidence increases
with age. OA is a major and growing health concern in developed
countries, owing to steadily increasing life expectancy and the
demand for better quality of life. Because of its chronic nature
and nonfatal outcome, OA affects the growing population of the
elderly over an increasing time span. Moreover, despite its
relatively benign character, OA is one of the most disabling
diseases; it is responsible for increasing financial and social
burdens in terms of medical treatments, forced inactivity, loss of
mobility, and dependence. Despite a growing awareness of OA as a
medical problem that has yet to reach its maximum impact on
society, there is a surprising absence of effective medical
treatments beyond pain control and surgery. So far, only
symptom-modifying drugs are available, while there remains a major
demand for disease-modifying treatments of proven clinical
efficacy. This demand will hopefully be met in the future by some
of the drugs that have been pressed into development and are now at
different stages of clinical investigation. Nevertheless, the
current lack of effective treatments reflects a still insufficient
knowledge of cartilage with respect to its metabolism, interactions
with other joint tissues, and causes and mechanisms (possibly of
very different nature) leading to failure of its turnover.
An indispensable collection of updated classical and emerging
techniques that promise to add critical knowledge to our
understanding of cartilage metabolism in health and disease. Volume
1: Cellular and Molecular Tools describes proven molecular and
cellular techniques for the in vitro study of normal and
osteoarthritic cartilage through biochemical, biomolecular,
immunological, and physical approaches, with emphasis on the
genetic manipulation of cells. Volume 2: Structure and In Vivo
Analysis, offers cutting-edge procedures for the study-at the
tissue level-of turnover, structure, and functioning of normal and
diseased articular cartilage by invasive and noninvasive means.
Comprehensive and up-to-date, the two volumes of Cartilage and
Osteoarthritis provide researchers and bench scientists with
readily reproducible protocols for new experiments to
understand-from the cellular to the animal level-the
pathophysiology of cartilage and to discover molecular targets for
pharmacological intervention.
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