This Second Volume in the series Handbook of Dynamic Data Driven Applications Systems (DDDAS) expands the scope of the methods and the application areas presented in the first Volume and aims to provide additional and extended content of the increasing set of science and engineering advances for new capabilities enabled through DDDAS. The methods and examples of breakthroughs presented in the book series capture the DDDAS paradigm and its scientific and technological impact and benefits. The DDDAS paradigm and the ensuing  DDDAS-based frameworks for systems’ analysis and design have been shown to engender new and advanced capabilities for understanding, analysis, and management of engineered, natural, and societal systems (“applications systems�), and for the commensurate wide set of scientific and engineering fields and applications, as well as foundational areas. The DDDAS book series aims to be a reference source of many of the important research and development efforts conducted under the rubric of DDDAS, and to also inspire the broader communities of researchers and developers about the potential in their respective areas of interest, of the application and the exploitation of the DDDAS paradigm and the ensuing frameworks, through the examples and case studies presented, either within their own field or other fields of study.  As in the first volume, the chapters in this book reflect research work conducted over the years starting in the 1990’s to the present.  Here, the theory and application content are considered for: Foundational Methods Materials Systems Structural Systems Energy Systems Environmental Systems: Domain Assessment & Adverse Conditions/Wildfires Surveillance Systems Space Awareness Systems Healthcare Systems Decision Support Systems Cyber Security Systems Design of Computer Systems  The readers of this book series will benefit from DDDAS theory advances such as object estimation, information fusion, and sensor management. The increased interest in Artificial Intelligence (AI), Machine Learning and Neural Networks (NN) provides opportunities for DDDAS-based methods to show the key role DDDAS plays in enabling AI capabilities;  address challenges that ML-alone does  not, and also show how ML in combination with DDDAS-based methods can deliver the advanced capabilities sought; likewise, infusion of DDDAS-like approaches in NN-methods strengthens such methods. Moreover, the “DDDAS-based Digital Twin� or “Dynamic Digital Twin�, goes beyond the traditional DT notion where the model and the physical system are viewed side-by-side in a static way, to a paradigm where the model dynamically interacts with the physical system through its instrumentation, (per the DDDAS feed-back control loop between model and instrumentation).

The Handbook of Dynamic Data Driven Applications Systems establishes an authoritative reference of DDDAS, pioneered by Dr. Darema and the co-authors for researchers and practitioners developing DDDAS technologies. Beginning with general concepts and history of the paradigm, the text provides 32 chapters by leading experts in ten application areas to enable an accurate understanding, analysis, and control of complex systems; be they natural, engineered, or societal: The authors explain how DDDAS unifies the computational and instrumentation aspects of an application system, extends the notion of Smart Computing to span from the high-end to the real-time data acquisition and control, and manages Big Data exploitation with high-dimensional model coordination. The Dynamically Data Driven Applications Systems (DDDAS) paradigm inspired research regarding the prediction of severe storms.  Specifically, the DDDAS concept allows atmospheric observing systems, computer forecast models, and cyberinfrastructure to dynamically configure themselves in optimal ways in direct response to current or anticipated weather conditions.  In so doing, all resources are used in an optimal manner to maximize the quality and timeliness of information they provide.                                             Kelvin Droegemeier, Regents’ Professor of Meteorology at the University of Oklahoma; former Director of the White House Office of Science and Technology Policy                                            We may well be entering the golden age of data science, as society in general has come to appreciate the possibilities for organizational strategies that harness massive streams of data. The challenges and opportunities are even greater when the data or the underlying system are dynamic - and DDDAS is the time-tested paradigm for realizing this potential.                           Sangtae Kim, Distinguished Professor of Mechanical Engineering and Distinguished Professor of Chemical Engineering at Purdue University

The Handbook of Dynamic Data Driven Applications Systems establishes an authoritative reference of DDDAS, pioneered by Dr. Darema and the co-authors for researchers and practitioners developing DDDAS technologies. Beginning with general concepts and history of the paradigm, the text provides 32 chapters by leading experts in ten application areas to enable an accurate understanding, analysis, and control of complex systems; be they natural, engineered, or societal: The authors explain how DDDAS unifies the computational and instrumentation aspects of an application system, extends the notion of Smart Computing to span from the high-end to the real-time data acquisition and control, and manages Big Data exploitation with high-dimensional model coordination. The Dynamically Data Driven Applications Systems (DDDAS) paradigm inspired research regarding the prediction of severe storms. Specifically, the DDDAS concept allows atmospheric observing systems, computer forecast models, and cyberinfrastructure to dynamically configure themselves in optimal ways in direct response to current or anticipated weather conditions. In so doing, all resources are used in an optimal manner to maximize the quality and timeliness of information they provide. Kelvin Droegemeier, Regents' Professor of Meteorology at the University of Oklahoma; former Director of the White House Office of Science and Technology Policy We may well be entering the golden age of data science, as society in general has come to appreciate the possibilities for organizational strategies that harness massive streams of data. The challenges and opportunities are even greater when the data or the underlying system are dynamic - and DDDAS is the time-tested paradigm for realizing this potential. Sangtae Kim, Distinguished Professor of Mechanical Engineering and Distinguished Professor of Chemical Engineering at Purdue University

This book constitutes the refereed proceedings of the Third International Conference on Dynamic Data Driven Application Systems, DDDAS 2020, held in Boston, MA, USA, in October 2020. The 21 full papers and 14 short papers presented in this volume were carefully reviewed and selected from 40 submissions. They cover topics such as: digital twins; environment cognizant adaptive-planning systems; energy systems; materials systems; physics-based systems analysis; imaging methods and systems; and learning systems.