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Interest in the ability of myocardium to adapt to ischaemic stress
has continued to grow since the discovery of ischaemic
preconditioning in 1986. In 1993, two reports heralded the
recognition of a delayed preconditioning response in the heart, now
commonly known as the second window' of protection. Since then, a
number of studies have described the ability of delayed
preconditioning and related adaptive phenomena to protect against a
variety of pathologies in the ischaemic and reperfused myocardium.
Our understanding of the cellular mechanisms of sub-acute adaptive
cardioprotection has advanced considerably during this period. This
compilation of state-of-the-art reviews by those who have made
significant contributions to this field provides detailed and
critical analysis of this research, from molecular basis to
potential clinical relevance. The book aims to provide an
authoritative, comprehensive and thoroughly up-to-date overview for
scientists and clinicians engaged in, or observing, this
rapidly-developing area of heart research. It will also be of
interest to those engaged in research on other tissues where
ischaemia-reperfusion pathology is of major concern.
Interest in the ability of myocardium to adapt to ischaemic stress
has continued to grow since the discovery of ischaemic
preconditioning in 1986. In 1993, two reports heralded the
recognition of a delayed preconditioning response in the heart, now
commonly known as the second window' of protection. Since then, a
number of studies have described the ability of delayed
preconditioning and related adaptive phenomena to protect against a
variety of pathologies in the ischaemic and reperfused myocardium.
Our understanding of the cellular mechanisms of sub-acute adaptive
cardioprotection has advanced considerably during this period. This
compilation of state-of-the-art reviews by those who have made
significant contributions to this field provides detailed and
critical analysis of this research, from molecular basis to
potential clinical relevance. The book aims to provide an
authoritative, comprehensive and thoroughly up-to-date overview for
scientists and clinicians engaged in, or observing, this
rapidly-developing area of heart research. It will also be of
interest to those engaged in research on other tissues where
ischaemia-reperfusion pathology is of major concern.
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