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Although the scientific literature on drug metabolism is extensive,
it suffers from the disadvantage that the material is diffuse and
consists largely of specialist monographs dealing with particular
aspects of the subject. In addi tion, although there are a few
excellent texts on drug metabolism in print, these tend to be
earlier publications and hence do not take into account the many
recent advances in this area. Our motivations for writing this book
therefore arose from the clear need for a recent and cohesive
introductory text on this subject, specifically designed to cater
for the needs of undergraduate and postgraduate students. Much of
the subject matter in this text is derived from various courses on
drug metabolism given at the University of Surrey and the
University of Glasgow to basic science students in pharmacology,
biochemistry, nutrition and nursing studies, to pre-clinical
medical students and to under graduate and post-graduate students
in toxicology. Therefore, it is our inten tion that this text will
serve as a primer in drug metabolism to a variety of students in
the life sciences taking courses in this subject. The term 'drug
metabolism' in its broadest sense may be considered as the
absorption, distribution, biotransformation and excretion of drugs.
To cover all these facets of drug metabolism in a single text is a
voluminous task and therefore we have focused primarily on the
biotransformation aspects of the subject.
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