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Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology - Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th-8th October 2000 (Paperback, Softcover reprint of hardcover 1st ed. 2001)
Otto-Wilhelm Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, …
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R5,771
Discovery Miles 57 710
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Ships in 10 - 15 working days
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More then 20 years have passed now since the first recombinant
protein producing microorganisms have been developed. In the
meanwhile, numerous proteins have been produced in bacteria, yeasts
and filamentous fungi, as weIl as higher eukaryotic cells, and even
entire plants and animals. Many recombinant proteins are on the
market today, and some of them reached substantial market volumes.
On the first sight one would expect the technology - including the
physiology of the host strains - to be optimised in detail after a
20 year's period of development. However, several constraints have
limited the incentive for optimisation, especially in the
pharmaceutical industry like the urge to proceed quickly or the
requirement to define the production parameters for registration
early in the development phase. The additional expenses for
registration of a new production strain often prohibits a change to
an optimised strain. A continuous optimisation of the entire
production process is not feasible for the same reasons.
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Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology - Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th-8th October 2000 (Hardcover, 2001 ed.)
Otto-Wilhelm Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, …
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R6,016
Discovery Miles 60 160
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Ships in 10 - 15 working days
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The general field of fundamental and applied biotechnology becomes
increasingly important for the production of biologicals for human
and veterinary use, by using prokaryotic and eukaryotic
microorganisms. The papers in the present book are refereed
articles compiled from oral and poster presentations from the EFB
Meeting on Recombinant Protein Production with Prokaryotic and
Eukaryotic Cells. A Comparative View on Host Physiology, which was
organized in Semmering/A from 5th to 8th October 2000. A special
feature of this meeting was the comparison of different classes of
host cells, mainly bacteria, yeasts, filamentous fungi, and animal
cells, which made obvious that many physiological features of
recombinant protein formation, like cell nutrition, stress
responses, protein folding and secretion, or genetic stability,
follow similar patterns in different expression systems. This
comparative aspect is by far the point of most interest because
such comparisons are rarely done, and if they are done, their
results are most often kept secret by the companies who generated
them. Audience: Presently, a comparable book does not exist because
the compiling of manuscripts from all fields of biotechnology
(prokaryotic as well as eukaryotic, up to animal cell
biotechnology) is not done in general. This particularity makes
this book very interesting for postgraduate students and
professionals in the large field of biotechnology who want to get a
more global view on the current state of the expression of
recombinant biologicals in different host cell systems, the
physiological problems associated with the use of different
expression systems, potential approaches to solve such difficulties
bymetabolic engineering or the use of other host cells, and the
cooperation between process development and strain improvement,
which is crucial for the optimisation of both the production strain
and the process. This book should be in every library of an
institution/organization involved in biotechnology.
A general trend in our modern society is a growing complexity. It
is therefore logical that in most countries there has been a
definite tendency to give weight to issues of adapting also the
physical space to this complexity and to find methods to do this in
an efficient way, giving satisfactory use of land and other natural
resources. During the twentieth century we have seen a very active
development of legal instruments for this purpose, aimed at
steering spatial planning and plan implementation according to the
objectives and policies chosen. This book presents basic
information on how different countries within the chosen area have
tried to solve the problem of establishing suitable systems of
steering spatial development by means of planning and
implementation measures. For this purpose summary descriptions of
the connected formal regulations in each country are given in an
appendix while a comparative presentation and discussion forms the
main text. This will give the interested reader an overview of the
current systems in Western Europe, how they have influenced each
other but still in many parts differ from each other.
Written by pioneers of the concept, this is the first complete
guide to the physical and engineering principles of Massive MIMO.
Assuming only a basic background in communications and statistical
signal processing, it will guide readers through key topics in
multi-cell systems such as propagation modeling, multiplexing and
de-multiplexing, channel estimation, power control, and performance
evaluation. The authors' unique capacity-bounding approach will
enable readers to carry out effective system performance analyses
and develop advanced Massive MIMO techniques and algorithms.
Numerous case studies, as well as problem sets and solutions
accompanying the book online, will help readers put knowledge into
practice and acquire the skill set needed to design and analyze
complex wireless communication systems. Whether you are a graduate
student, researcher, or industry professional working in the field
of wireless communications, this will be an indispensable guide for
years to come.
Originally published in 1959, this book contains the noted
discussions of the second conference on the co-ordination of
galactic research, held at Saltsjoebaden, near Stockholm, in June
1957, by the International Astronomical Union. 'The editorial work
in preparing the present report has been shared by six of the
participants of the conference' and 'in accordance with a decision
taken at the Stockholm conference, an attempt has been made to
present the material in the same way as the report of the Groningen
conference of 1953'. Notably, the differences in how the editors
have presented the material 'add a certain variety in the way of
presentation of the subjects'. Topics are detailed and varied;
topic titles include, 'Clusters and associations', 'Spiral
structure' and 'The magellanic clouds'. This book, containing
symposium number seven, will be of significant value to anyone with
an interest in astronomy, cosmology and the history of physics.
Space-time coding is a technique that promises greatly improved
performance in wireless networks by using multiple antennas at the
transmitter and receiver. Space-Time Block Coding for Wireless
Communications, first published in 2003, is an introduction to the
theory of this technology. The authors develop the topic using a
unified framework and cover a variety of topics ranging from
information theory to performance analysis and space-time coding
methods for both flat and frequency-selective fading
multiple-antenna channels. The authors concentrate on key
principles rather than specific practical applications, and present
the material in a concise and accessible manner. Their treatment
reviews the fundamental aspects of multiple-input, multiple-output
communication theory, and guides the reader through a number of
topics at the forefront of research and development. The book
includes homework exercises and is aimed at graduate students and
researchers working on wireless communications, as well as
practitioners in the wireless industry.
Space-time coding is a technique that promises greatly improved performance in wireless networks by using multiple antennas at the transmitter and receiver. Space-Time Block Coding for Wireless Communications is an introduction to the theory of this technology. The authors develop the topic using a unified framework and cover a variety of topics ranging from information theory to performance analysis and state-of-the-art space-time coding methods for both flat and frequency-selective fading multiple-antenna channels. The authors concentrate on key principles rather than specific practical applications, and present the material in a concise and accessible manner. Their treatment reviews the fundamental aspects of multiple-input, multiple output communication theory, and guides the reader through a number of topics at the forefront of current research and development. The book includes homework exercises and is aimed at graduate students and researchers working on wireless communications, as well as practitioners in the wireless industry.
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