More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons.

The general field of fundamental and applied biotechnology becomes increasingly important for the production of biologicals for human and veterinary use, by using prokaryotic and eukaryotic microorganisms. The papers in the present book are refereed articles compiled from oral and poster presentations from the EFB Meeting on Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology, which was organized in Semmering/A from 5th to 8th October 2000. A special feature of this meeting was the comparison of different classes of host cells, mainly bacteria, yeasts, filamentous fungi, and animal cells, which made obvious that many physiological features of recombinant protein formation, like cell nutrition, stress responses, protein folding and secretion, or genetic stability, follow similar patterns in different expression systems. This comparative aspect is by far the point of most interest because such comparisons are rarely done, and if they are done, their results are most often kept secret by the companies who generated them. Audience: Presently, a comparable book does not exist because the compiling of manuscripts from all fields of biotechnology (prokaryotic as well as eukaryotic, up to animal cell biotechnology) is not done in general. This particularity makes this book very interesting for postgraduate students and professionals in the large field of biotechnology who want to get a more global view on the current state of the expression of recombinant biologicals in different host cell systems, the physiological problems associated with the use of different expression systems, potential approaches to solve such difficulties bymetabolic engineering or the use of other host cells, and the cooperation between process development and strain improvement, which is crucial for the optimisation of both the production strain and the process. This book should be in every library of an institution/organization involved in biotechnology.

A general trend in our modern society is a growing complexity. It is therefore logical that in most countries there has been a definite tendency to give weight to issues of adapting also the physical space to this complexity and to find methods to do this in an efficient way, giving satisfactory use of land and other natural resources. During the twentieth century we have seen a very active development of legal instruments for this purpose, aimed at steering spatial planning and plan implementation according to the objectives and policies chosen. This book presents basic information on how different countries within the chosen area have tried to solve the problem of establishing suitable systems of steering spatial development by means of planning and implementation measures. For this purpose summary descriptions of the connected formal regulations in each country are given in an appendix while a comparative presentation and discussion forms the main text. This will give the interested reader an overview of the current systems in Western Europe, how they have influenced each other but still in many parts differ from each other.

Written by pioneers of the concept, this is the first complete guide to the physical and engineering principles of Massive MIMO. Assuming only a basic background in communications and statistical signal processing, it will guide readers through key topics in multi-cell systems such as propagation modeling, multiplexing and de-multiplexing, channel estimation, power control, and performance evaluation. The authors' unique capacity-bounding approach will enable readers to carry out effective system performance analyses and develop advanced Massive MIMO techniques and algorithms. Numerous case studies, as well as problem sets and solutions accompanying the book online, will help readers put knowledge into practice and acquire the skill set needed to design and analyze complex wireless communication systems. Whether you are a graduate student, researcher, or industry professional working in the field of wireless communications, this will be an indispensable guide for years to come.

Originally published in 1959, this book contains the noted discussions of the second conference on the co-ordination of galactic research, held at Saltsjoebaden, near Stockholm, in June 1957, by the International Astronomical Union. 'The editorial work in preparing the present report has been shared by six of the participants of the conference' and 'in accordance with a decision taken at the Stockholm conference, an attempt has been made to present the material in the same way as the report of the Groningen conference of 1953'. Notably, the differences in how the editors have presented the material 'add a certain variety in the way of presentation of the subjects'. Topics are detailed and varied; topic titles include, 'Clusters and associations', 'Spiral structure' and 'The magellanic clouds'. This book, containing symposium number seven, will be of significant value to anyone with an interest in astronomy, cosmology and the history of physics.

Space-time coding is a technique that promises greatly improved performance in wireless networks by using multiple antennas at the transmitter and receiver. Space-Time Block Coding for Wireless Communications, first published in 2003, is an introduction to the theory of this technology. The authors develop the topic using a unified framework and cover a variety of topics ranging from information theory to performance analysis and space-time coding methods for both flat and frequency-selective fading multiple-antenna channels. The authors concentrate on key principles rather than specific practical applications, and present the material in a concise and accessible manner. Their treatment reviews the fundamental aspects of multiple-input, multiple-output communication theory, and guides the reader through a number of topics at the forefront of research and development. The book includes homework exercises and is aimed at graduate students and researchers working on wireless communications, as well as practitioners in the wireless industry.

Space-time coding is a technique that promises greatly improved performance in wireless networks by using multiple antennas at the transmitter and receiver. Space-Time Block Coding for Wireless Communications is an introduction to the theory of this technology. The authors develop the topic using a unified framework and cover a variety of topics ranging from information theory to performance analysis and state-of-the-art space-time coding methods for both flat and frequency-selective fading multiple-antenna channels. The authors concentrate on key principles rather than specific practical applications, and present the material in a concise and accessible manner. Their treatment reviews the fundamental aspects of multiple-input, multiple output communication theory, and guides the reader through a number of topics at the forefront of current research and development. The book includes homework exercises and is aimed at graduate students and researchers working on wireless communications, as well as practitioners in the wireless industry.