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"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.
The success of any drug discovery project relies upon the quality
of the lead that initiates the lead optimization process. What
defines a quality lead, where these quality leads come from and how
one discovers them has been the subject of intense debate within
the pharmaceutical industry, relies upon defining those properties
that historically have led to successful drug discovery. This
volume addresses these questions and specifically discusses
diabetes, obesity and tuberculosis.
While making the pilgrimage from Holland to America in 1620 with other English Separatists, teenaged Mary Chilton endures many hardships that test her faith in God.
This volume provides reviews of six topics demonstrating the
breadth of the field and recent successes in medicinal chemistry.
Each of the first five chapters takes an important biochemical
target as its theme and provides an insight into current progress
in drug design. The last chapter focuses on the vital subject of
pharmacokinetics and the great strides that have been made in this
discipline during the past decade. All chapters provide an insight
into the skills required of the modern medicinal chemist, in
particular, the use of an appropriate selection of the wide range
of tools now available to solve key scientific problems.
The perceived lack of drug discovery productivity in recent times
has led to much debate in the pharmaceutical/biotechnology industry
as escalating R&D costs are not being matched by increased
output. Few observers doubt that selecting the right targets, ie
those which are critical to disease pathology and are druggable, is
the best starting point for improved productivity.
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.
Once upon a time there was an Algonquin princess named Pocahontas,
a curious 10-year-old who loved exploring the tidewater lands of
her people. One day she encounters strangers, a group of people
that look different from her own. She befriends them, and when her
people come into conflict with these new settlers, Pocahontas steps
in to save the life of one of them by offering her own. Based on
the true story of Pocahontas' early life.
The "Daughters of the Faith" series has been a great success for
Moody so far with 120,000 copies sold. "Courage to Run" is the most
successful, with sales of 39,000. "Tinker's Daughter" is the next
highest, at more than 19,000. They are all continuing to grow.
"Progress in Medicinal Chemistry" provides a review of eclectic
developments in medicinal chemistry. This volume continues in the
serial's tradition of providing an insight into the skills required
of the modern medicinal chemist; in particular, the use of an
appropriate selection of the wide range of tools now available to
solve key scientific problems. *Presents the latest research in the field of drug discovery *Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Appropriate selection of biochemical targets is one of the most
important drivers of cost effectiveness in the discovery of new
medicines. Despite the many advances in genetics, genomics and
systems biology, 'validation' of a target is not achieved until
therapeutic efficacy is demonstrated by a drug candidate. Volume 46
of this series reviews the medicinal chemistry aimed at six diverse
targets from which important new medicines are emerging:
The Progress in Medicinal Chemistry series spans a wide range of
topics of interest to the drug discovery community. This particular
volume touches upon the following: Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier's extensive researcher network. For more information about the Elsevier Book Series on
ScienceDirect Program, please visit:
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