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A new phase of anti-epileptic drugs (AEDs) investigation has begun
in which new drugs can be designed to target specific epileptogenic
mechanisms. A rational approach to therapy today requires not only
a full awareness of phamacokinetics of AEDs but also a thorough
knowledge of their molecular targets and of their influence on
excitatory and inhibitory mechanisms in the brain. This book
provides a multi-author systematic look at this subject, from
neurobiological bases to clinical applications. It includes four
sections dealing with fundamental aspects of cortical excitability,
models of epileptic disorders, targets for anti-epileptic drugs and
rational approaches to therapy. Each chapter provides a review of a
specific topic prepared by well known scientists active in the
field, introducing their most recent results in a concise and
comprehensive form.
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Paperback
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R398
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