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The gastrointestinal tract has a number of unique features. Its
extensive surface is formed by a single layer of rapidly renewing
cells, the intestinal epithelial cells. These cells are in contact
with a number of other cell populations, including the largest part
of the immune system, and with an excessive luminal antigen load,
including vast numbers of bacteria. Furthermore two more organs,
namely liver and pancreas, are part of the system. The rapid
renewal of the epithelial layer, the interactions of different cell
types, and the balance between cell proliferation and death, have
been fascinating subjects of studies in recent years. Much has been
learned, and cytokines have emerged as important mediators for all
these interactions and homeostatic systems. This book, the
proceedings of the Falk Symposium 113 on `Cytokines and Cell
Homeostasis in the Gastrointestinal Tract', held in Regensburg,
Germany, 16-18 September 1999, provides a forum for basic
scientists and interested clinicians to exchange ideas, to discuss
concepts and to plan further studies.
Although the first description of patients with what we now call
Crohn's disease or ulcerative colitis was published well before
1900, both disorders seem to be diseases of the twentieth century.
At the very start of the twenty-first century, it therefore seems
appropriate to look back and at the same time look forward and to
assess what knowledge has been gained during the last 100 years and
in what direction research and thereby clinical practice will go in
the future. This book, the proceedings of Falk Symposium No. 111
held in Freiburg, Germany, on June 19-20 1999, contains
contributions from experienced senior scientists on the state of
the art in pathophysiology, diagnosis and treatment, together with
unpublished and new findings from young researchers. Basic
scientists and clinicians are thereby involved in an exchange of
information which will lead to new directions for future research
and clinical management of inflammatory bowel diseases.
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