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Heart transplantation remains one of the major scientific
achievements of twentieth century medicine. During the past four
decades, it has evolved from an unproven experimental surgical
technique to the most effective form of therapy for refractory
end-stage heart disease. It has captured the public's imagination
and expanded our understanding of fundamental immunologic
mechanisms that are responsible for cellular and humorally-mediated
immunity. Despite its successes, many clinical and scientific
problems remain. One or more bouts of acute cellular or humoral
(vascular) rejection will occur in over 75% of transplant
recipients despite current immunosuppressive strategies. Further,
rejection directly results in approximately 20% of post-transplant
deaths and is believed to play a major role in the development of
late allograft dysfunction and coronary vasculopathy. This book by
international experts in the fields of transplantation medicine,
immunobiology and cardiac imaging provides the reader with an
up-to-date, consise summary of the latest developments in the
diagnosis and treatment of acute cardiac rejection. It is axiomatic
that a more complete understanding of the pathogenic processes
involved in rejection will ultimately lead to its prevention. This
volume will be useful to transplant cardiologists, cardiovascular
surgeons, cardiac pathologists and transplant scientists who seek
to prolong the lifespan and improve the quality of life of their
transplant recipients.
Heart transplantation remains one of the major scientific
achievements of twentieth century medicine. During the past four
decades, it has evolved from an unproven experimental surgical
technique to the most effective form of therapy for refractory
end-stage heart disease. It has captured the public's imagination
and expanded our understanding of fundamental immunologic
mechanisms that are responsible for cellular and humorally-mediated
immunity. Despite its successes, many clinical and scientific
problems remain. One or more bouts of acute cellular or humoral
(vascular) rejection will occur in over 75% of transplant
recipients despite current immunosuppressive strategies. Further,
rejection directly results in approximately 20% of post-transplant
deaths and is believed to play a major role in the development of
late allograft dysfunction and coronary vasculopathy. This book by
international experts in the fields of transplantation medicine,
immunobiology and cardiac imaging provides the reader with an
up-to-date, consise summary of the latest developments in the
diagnosis and treatment of acute cardiac rejection. It is axiomatic
that a more complete understanding of the pathogenic processes
involved in rejection will ultimately lead to its prevention. This
volume will be useful to transplant cardiologists, cardiovascular
surgeons, cardiac pathologists and transplant scientists who seek
to prolong the lifespan and improve the quality of life of their
transplant recipients.
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