Four episodes from the children's animation following a little girl who becomes a princess. When her mother marries the king, Sofia (voice of Ariel Winter) becomes a member of the royal family overnight and moves into their grand palace. In this instalment, after receiving a book of secrets from her Aunt Tilly (Bonnie Hunt), Sofia finds her destiny is to become the new Story Keeper of the castle's secret library. The episodes are: 'Princess Adventure Club', 'The Secret Library', 'The Princess Ballet', 'The Secret Library: Olaf and the Tale of Miss Nettle'.

There's a war against truth... and if we don't win it, intellectual freedom will be a casualty.

The West’s commitment to freedom, reason, and true liberalism has never been more seriously threatened than it is today by the stifling forces of political correctness.

Dr. Gad Saad, the host of the enormously popular YouTube show THE SAAD TRUTH, exposes the bad ideas—what he calls “idea pathogens”—that are killing common sense and rational debate. Incubated in our universities and spread through the tyranny of political correctness, these ideas are endangering our most basic freedoms—including freedom of thought and speech.

The danger is grave, but as Dr. Saad shows, politically correct dogma is riddled with logical fallacies. We have powerful weapons to fight back with—if we have the courage to use them.

A provocative guide to defending reason and intellectual freedom and a battle cry for the preservation of our fundamental rights, The Parasitic Mind will be the most controversial and talked-about book of the year.

This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: * The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. * Study directors and principal investigators. * The nuts and bolts of study performance. * Electronic reporting requirements - SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). * Consultants and their roles. * An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs - where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities - and for auditing studies and projects at such facilities - are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.

Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.

The last 10 years have seen a seismic shift in therapeutic product development and testing. In both the pharmaceutical (both small and large molecule) and medical device sectors, the vast majority of testing and evaluation of products is not performed within innovator companies, but rather has been outsourced to a growing universe of commercial organizations. The authors both have more than 30 years experience in this field, and both have worked within innovator companies, for CROs, and as consultants in the field. "Contract Research and Development Organizations: Their Role in Global Product Development" has been crafted by these authors to provide a how to guide for all aspects of working with CROs in selecting, working with and ensuring the best possible desirable outcome of having the R&D function, or substantial parts of it, outsourced. It uses as the exemplary case nonclinical safety assessment, biocompatibility and efficacy testing which are to be performed to select the best possible candidate compound, device or formulation and then moving the resulting regulated therapeutic medical product into and through the development process and to marketing approval. But also covered are the contract synthesis of drug substances and corresponding manufacture of biologics and manufacture of products, formulation development, clinical evaluation, regulatory and document preparation support, and use of consultants.

Included in the volume are an exhaustive listing of those CROs in the (drug and device) safety evaluation sector and their contact information and capabilities, and extensive similar listing for the other types of contract service providers. Also included are guidances on how to monitor ongoing work at contract facilities and audit check lists for GLP, GMP and GCP facilities. These listings are international in scope, and a specific chapter addresses working with some of the newer international CROs. "

Only God knows. We may ponder and choose our own path to receiving His Word, but we must realize ours is a human path. We cannot let blind faith, tradition, and ritual cloud our judgment and determine our perception of the world. The potent mix of fanaticism (whether tied to a nation or a religion), ignorance, and emotion has driven wedges among the peoples of the earth-wedges that need not exist at all. "In Search of God: God, Religious Scriptures, and Proof of Divine Revelation" presents the result of author Dr. Mohamed Gad's twenty-five-year study of Christian, Islamic, and Judaic scripture, revealing the unifying truths of divinity, belief, and faith."In Search of God" challenges serious students of all faiths and backgrounds as it examines proof for the existence of God, creation and evolution, prophecy, the identity of Jesus, the concept of the Holy Trinity, and the commonalities and spirit of revelation of the world's three major religions. Dr. Gad's personal journey and critical, spiritual investigation personify the human desire to understand God's intention for us. Yes, only God knows, but armed with truth and tolerance we now have a chance to create a brighter future for our children and ourselves, a future in which we seek God, trust in Him, and are at peace.

All individuals who operate in the business sphere, whether as consumers, employers, employees, entrepreneurs, or financial traders to name a few constituents, share a common biological heritage and are defined by a universal human nature. As such, it is surprising that so few business scholars have incorporated biological and evolutionary-informed theories within their conceptual toolboxes. This edited book addresses this lacuna by culling chapters at the intersection of the evolutionary behavioral sciences and specific business contexts including in marketing, consumer behavior, advertising, innovation and creativity, intertemporal choice, negotiations, competition and cooperation in organizational settings, sex differences in workplace patterns, executive leadership, business ethics, store design, behavioral decision making, and electronic communication. To reword the famous aphorism of T. G. Dobzhansky, nothing in business makes sense except in the light of evolution.

Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: -The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies -Coverage of Bayesian analysis and data analysis in pharmacology and toxicology -Almost 200 problems with solutions -Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology -A new chapter explaining the basics of Good Laboratory Practices (GLPs) -For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.

- Written by two leading world experts on dyslexia - This book's structure represents a move from the 'wait to fail' model to a 'test to teach' approach. - increasingly the educational system has required an enhanced role for teachers in the identification and progress monitoring of their student's educational needs - Will have a global appeal as not linked to a specific curriculum

In the last four decades of the twentieth century the use of sweetpotato was diversified beyond their classification as subsistence, food security, and famine-relief crop. In developing countries they serve both as human food and for feeding livestock. In Western countries they appeal to health conscious consumers because of their nutritional aspects. The sweetpotato is very high in nutritive value, and merits wider use on this account alone. The book has 2 parts. A general one giving up-to-date information on the history, botany, cultivars, genetic engineering, propagation, diseases and pests, nutritional data and marketing; and a second part presenting data on sweetpotato growing practices in different areas of the world. The information should be useful to researchers, practitioners and crop administrators in different countries.

This book is a first attempt to link well-known plant resistance phenomena with emerging concepts in molecular biology. Resistance phenomena such as the local lesion response, induced resistance, "green islands" and resistance in various crop plants are linked with new information on gene-silencing mechanisms, gene silencing suppressors, movement proteins and plasmodesmatal gating, downstream signalling components, and more.

The inspiration for this text was the 1988 volume by Alder and Zbinden, written before the ICH harmonization process for drug safety evaluation (or its ISO analog for device biocompatibility evaluation) had been initiated or come to force. Since then, much has changed in both the world and practice of medicine and the regulation of drugs. The intent of this volume is to provide similar guidance as to what nonclinical safety assessment tests need to be performed to move a drug into man, through development and to market approved (this intent was subsequently extended to cover the closely related medical device biotechnology, and combination product fields) in a concise, abbreviated manner for all the major world market countries.

Designing satellite structures poses an ongoing challenge as the interaction between analysis, experimental testing, and manufacturing phases is underdeveloped. "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing "explains the theoretical and practical knowledge needed to perform design of satellite structures. By layering detailed practical discussions with fully developed examples, "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing" provides the missing link between theory and implementation.

Computational examples cover all the major aspects of advanced analysis; including modal analysis, harmonic analysis, mechanical and thermal fatigue analysis using finite element method. Test cases are included to support explanations an a range of different manufacturing simulation techniques are described from riveting to shot peening to material cutting. Mechanical design of a satellites structures are covered in three steps: analysis step under design loads, experimental testing to verify design, and manufacturing.

Stress engineers, lecturers, researchers and students will find "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing "a key guide on with practical instruction on applying manufacturing simulations to improve their design and reduce project cost, how to prepare static and dynamic test specifications, and how to use finite element method to investigate in more details any component that may fail during testing. "

Out of the House of Bondage, first published in 1986, focuses not on slave rebellions, which were of crucial importance but not common occurrences, but on the day-to-day patterns of resistance that directly affected the lives of slaves. It examines acts of resistance in both the Americas and Africa, and widens the study of runaways and resistance and uses runaways as a means to further analyse slavery and the wider slave population.

I wrote this book to tell an important story about a boy from a wealthy Jewish family who escaped and survive Nazi Germany. His parents and his sister were killed outside the Lodge concentration camp in 1941. The book begins with the history of the grandparents and the parents to the time when the boy found himself with other boys. They saw their parents quickly fading in the distance as the locomotive started to pull them into an unknown journey. The boy's father was wealthy enough to secure for Hans, a place with the Kinder-Transport. By train and boat the boys arrived in England were they were received by families who had volunteered to bring these 'refuge children' into their homes. Hans was fortunate enough to be assigned to an affluent family, who lived near London. After several months Hans was informed that there had been a conversation about adoption between his host and his father. He opted to go to school on his own and eventually make his way to Palestine. After attending classes at several locations, Hans and some of his friends were located to Chester. That is were he found himself when World War II broke out. Two weeks before his graduation, he and all his friends were shipped to a farm in Lancashire were they were taught farming in preparation for Kibbutz-life in Palestine. The last stop for Hans was in Kindersley, Shropshire where Hans had a very successful career as a dairy-man. But when the group of boys and girls had to register as 'Friendly German Enemy Aliens', Hans and several others opted to volunteer for the 'JEWISH BRIGADE'. It was because of his service with the Brigade that Hans would find a way to fulfill his dream to go to Palestine.

- Written by two leading world experts on dyslexia - This book's structure represents a move from the 'wait to fail' model to a 'test to teach' approach. - increasingly the educational system has required an enhanced role for teachers in the identification and progress monitoring of their student's educational needs - Will have a global appeal as not linked to a specific curriculum