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This collection of papers represents an edited version of the
Proceedings of the 9th European Symposium on Metabolism which was
held at the University of Padua (Italy) from October 12-14, 2006.
As did the Symposium itself, this work unites under a single cover
topics dealing with four important metabolic alterations: diabetes,
obesity, hyperlipidemia and hypertension. Of vital interest to the
scientific community because of their cost in human life and
medical expenditure, the latest edition of this Symposium received
much attention from investigators in these fields. The 2006 edition
focusses on the most recent epidemiologic findings on the role of
oxidative stress and of endothelial dysfunction on the development
of atherosclerosis. Other topics of particular interest are:
abdominal obesity, pro-inflammatory adipokines and atherogenesis;
the metabolic syndrome and cardiovascular global risk; coronary and
cerebrovascuclar disease in diabetes and in the metabolic syndrome.
Finally, the management, prevention and treatment of the metabolic
syndrome and its cardiovascular complications are examined in the
light of several recent clinical trials in these fields. This
volume will certainly be of interest to all those practitioners and
specialists who are looking for a broad, though specific overview
on several aspects of insulin resistance as a possible pathogenetic
mechanism and a guide to preventing and treating the metabolic
syndrome and its cardiovascular complications in their patients.
Basic and clinical research have in recent years contributed
towards clarifying certain aspects ofthe epidemiology,
pathogenesis, prevention, and treatment of liver diseases. New
diagnostic techniques have, moreover, facilitated observations on
the evolution of such diseases. Nevertheless, a numberofquestions
still remain, especially in the assess- ment and management ofliver
patients. The hope that such questions can be answered justifies
publications like the present one, which provide experts an
opportunity to pre- sent the results oftheir research. The papers
collected in this volume cover all aspects of the assessment and
man- agement of hepatobiliary disease. The focal points are three
summaries ofthe state of the art. The first deals with the highly
topical problem of liver transplants from the point ofview
ofpatient selection. Roger Williams in fact stresses the urgent
need to ex- ercise caution in the selection ofsuitable candidates.
This is especially true at the pre- sent time when cyclosporin A, a
new immunosuppressive drug now available on the market, has
significantly changed the natural history ofsurvival after liver
transplanta- tion.
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