Immune landscape of pancreatic cancer development and drug resistance explores the advances in immune-based therapies aimed at harnessing the power of the immune system against pancreatic cancer and rewiring tumor microenvironments to eradicate pancreatic cells. With a strong focus on the development of therapeutic methods to improve the survival rates of pancreatic cancer, this book also shows the latest trends in immune targeted approaches for pancreatic cancer treatment. In 12 chapters Immune landscape of pancreatic cancer development and drug resistance discusses the current understanding of PC development and its various mutational and immune features and explore some of the new immune-based therapies aimed at targeting pancreatic cancer. It covers the urgent need for developing novel therapeutic modalities and aims at delineating future fields and avenues of research in pancreatic cancer treatment. The book provides the reader with an updated understanding of the immune landscape of PC and an all-encompassing overview of the latest trends in immune targeted approaches for PC treatment. This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic cancer.

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies. This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer for their research work or clinical setting.

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs.

Control volume finite element methods (CVFEM) bridge the gap between finite difference and finite element methods, using the advantages of both methods for simulation of multi-physics problems in complex geometries. In Hydrothermal Analysis in Engineering Using Control Volume Finite Element Method, CVFEM is covered in detail and applied to key areas of thermal engineering. Examples, exercises, and extensive references are used to show the use of the technique to model key engineering problems such as heat transfer in nanofluids (to enhance performance and compactness of energy systems), hydro-magnetic techniques in materials and bioengineering, and convective flow in fluid-saturated porous media. The topics are of practical interest to engineering, geothermal science, and medical and biomedical sciences.

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research and computational approaches for drug discovery and repurposing for cancer therapy. The book provides detailed descriptions about target molecules and pathways and their inhibitors for easy understanding and applicability. Users will find discussions on tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers and transcriptome which are discussed in the context of different cancer types, such as colon, glioblastoma, endometrial and retinoblastoma, amongst others. This book will be a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor treatments for cancer patients.

Heat Transfer Enhancement Using Nanofluid Flow in Microchannels: Simulation of Heat and Mass Transfer focuses on the numerical simulation of passive techniques, and also covers the applications of external forces on heat transfer enhancement of nanofluids in microchannels. Economic and environmental incentives have increased efforts to reduce energy consumption. Heat transfer enhancement, augmentation, or intensification are the terms that many scientists employ in their efforts in energy consumption reduction. These can be divided into (a) active techniques which require external forces such as magnetic force, and (b) passive techniques which do not require external forces, including geometry refinement and fluid additives.

This book seeks to comprehensively cover recent progress in computational fluid dynamics and nonlinear science and its applications to MHD and FHD nanofluid flow and heat transfer. The book will be a valuable reference source to researchers in various fields, including materials science, nanotechnology, mathematics, physics, information science, engineering and medicine, seeing to understand the impact of external magnetic fields on the hydrothermal behavior of nanofluids in order to solve a wide variety of theoretical and practical problems.

With Application of Nonlinear Systems in Nanomechanics and Nanofluids the reader gains a deep and practice-oriented understanding of nonlinear systems within areas of nanotechnology application as well as the necessary knowledge enabling the handling of such systems. The book helps readers understand relevant methods and techniques for solving nonlinear problems, and is an invaluable reference for researchers, professionals and PhD students interested in research areas and industries where nanofluidics and dynamic nano-mechanical systems are studied or applied. The book is useful in areas such as nanoelectronics and bionanotechnology, and the underlying framework can also be applied to other problems in various fields of engineering and applied sciences.

The realities of Iranian life are far more harrowing than most people imagine from the outside. Ganji paints a portrait of duplicitous clerics arbitrarily arresting, torturing, mutilating, and executing citizens, all in the name of Islamic Justice. A system of apartheid has been instituted against women. While 60% of the population lives below the poverty line, the mullah regime has hoarded billions of dollars in accounts and properties in Europe, Canada, and Japan. Roughly 70% of the population is under 30 years of age and opposes the regime. In the year of 2001 alone, 220,000 people--mostly educated youth--left the country in search of better lives. Ganji stresses that the best defense against terrorism is offense, and that the United States can and must establish a proactive policy of helping Iranians struggling for the freedom of Iran, in and out of the country.

Western policies toward the Iranian mullah regime have thus far been reactionary rather than proactive. The regime in Iran has been an incubator of international terrorism, aiding and abetting international terrorist groups in and out of the Middle East. The author argues that now is the time for the United States to substitute rhetoric with action in policies toward the ruling clerics in Iran.

Dynamical and vibratory systems are basically an application of mathematics and applied sciences to the solution of real world problems. Before being able to solve real world problems, it is necessary to carefully study dynamical and vibratory systems and solve all available problems in case of linear and nonlinear equations using analytical and numerical methods. It is of great importance to study nonlinearity in dynamics and vibration; because almost all applied processes act nonlinearly, and on the other hand, nonlinear analysis of complex systems is one of the most important and complicated tasks, especially in engineering and applied sciences problems.
There are probably a handful of books on nonlinear dynamics and vibrations analysis. Some of these books are written at a fundamental level that may not meet ambitious engineering program requirements. Others are specialized in certain fields of oscillatory systems, including modeling and simulations. In this book, we attempt to strike a balance between theory and practice, fundamentals and advanced subjects, and generality and specialization. None of the books in this area have completely studied and analyzed nonlinear equation in dynamical and vibratory systems using the latest analytical and numerical methods, so that the user can solve the problems without the need of studying too many different references. Thereby in this book, by the use of the latest analytic, numeric laboratorial methods and using more than 300 references like books, papers and the researches done by the authors and by considering almost all possible processes and situation, new theories has been proposed to encounter applied problems in engineering and applied sciences. In this way, the user (bachelor's, master's and PhD students, university teachers and even in research centers in different fields of mechanical, civil, aerospace, electrical, chemical, applied mathematics, physics, and etc.) can encounter such systems confidently. In the different chapters of the book, not only are the linear and especially nonlinear problems with oscillatory form broadly discussed, but also applied examples are practically solved by the proposed methodology.

This book addresses the issue of Machine Learning (ML) attacks on Integrated Circuits through Physical Unclonable Functions (PUFs). It provides the mathematical proofs of the vulnerability of various PUF families, including Arbiter, XOR Arbiter, ring-oscillator, and bistable ring PUFs, to ML attacks. To achieve this goal, it develops a generic framework for the assessment of these PUFs based on two main approaches. First, with regard to the inherent physical characteristics, it establishes fit-for-purpose mathematical representations of the PUFs mentioned above, which adequately reflect the physical behavior of these primitives. To this end, notions and formalizations that are already familiar to the ML theory world are reintroduced in order to give a better understanding of why, how, and to what extent ML attacks against PUFs can be feasible in practice. Second, the book explores polynomial time ML algorithms, which can learn the PUFs under the appropriate representation. More importantly, in contrast to previous ML approaches, the framework presented here ensures not only the accuracy of the model mimicking the behavior of the PUF, but also the delivery of such a model. Besides off-the-shelf ML algorithms, the book applies a set of algorithms hailing from the field of property testing, which can help to evaluate the security of PUFs. They serve as a "toolbox", from which PUF designers and manufacturers can choose the indicators most relevant for their requirements. Last but not least, on the basis of learning theory concepts, the book explicitly states that the PUF families cannot be considered as an ultimate solution to the problem of insecure ICs. As such, it provides essential insights into both academic research on and the design and manufacturing of PUFs.

Engineering applications offer benefits and opportunities across a range of different industries and fields. By developing effective methods of analysis, results and solutions are produced with higher accuracy. Numerical and Analytical Solutions for Solving Nonlinear Equations in Heat Transfer is an innovative source of academic research on the optimized techniques for analyzing heat transfer equations and the application of these methods across various fields. Highlighting pertinent topics such as the differential transformation method, industrial applications, and the homotopy perturbation method, this book is ideally designed for engineers, researchers, graduate students, professionals, and academics interested in applying new mathematical techniques in engineering sciences. Topics Covered: Adomian Decomposition Method Differential Transformation Method Homotopy Analysis Method Homotopy Perturbation Method Industrial applications Variational Iteration Method

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Application of Semi-Analytical Methods for Nanofluid Flow and Heat Transfer applies semi-analytical methods to solve a range of engineering problems. After various methods are introduced, their application in nanofluid flow and heat transfer, magnetohydrodynamic flow, electrohydrodynamic flow and heat transfer, and nanofluid flow in porous media within several examples are explored. This is a valuable reference resource for materials scientists and engineers that will help familiarize them with a wide range of semi-analytical methods and how they are used in nanofluid flow and heat transfer. The book also includes case studies to illustrate how these methods are used in practice.

Differential Transformation Method for Mechanical Engineering Problems focuses on applying DTM to a range of mechanical engineering applications. The authors modify traditional DTM to produce two additional methods, multi-step differential transformation method (Ms-DTM) and the hybrid differential transformation method and finite difference method (Hybrid DTM-FDM). It is then demonstrated how these can be a suitable series solution for engineering and physical problems, such as the motion of a spherical particle, nanofluid flow and heat transfer, and micropolar fluid flow and heat transfer.

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer.

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy.

Nonlinear Heat Transfer: Mathematical Modeling and Analytical Methods addresses recent progress and original research in nonlinear science and its application in the area of heat transfer, with a particular focus on the most important advances and challenging applications. The importance of understanding analytical methods for solving linear and nonlinear constitutive equations is essential in studying engineering problems. This book provides a comprehensive range of (partial) differential equations, applied in the field of heat transfer, tackling a comprehensive range of nonlinear mathematical problems in heat radiation, heat conduction, heat convection, heat diffusion and non-Newtonian fluid systems. Providing various innovative analytical techniques and their practical application in nonlinear engineering problems is the unique point of this book. Drawing a balance between theory and practice, the different chapters of the book focus not only on the broader linear and nonlinear problems, but also applied examples of practical solutions by the outlined methodologies.

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis.This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.