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The present work focuses on the development of hydrodynamically
balanced delivery system of Aceclofenac as a single-unit floating
Tablet. Floating effervescent tablets were formulated by various
materials like. HPMC, K4M, K 15M, psyllium husk, swelling agent as
crospovidone and micro crystalline cellulose and gas generating
agent like sodium bicarbonate and citric acid. Floating non
effervescent tablets were prepared by polypropylene foam powder and
different matrix forming polymers. The prepared floating tablets
were evaluated for various Parameter. The formulation was optimized
on the basis of in vitro buoyancy and in vitro release By fitting
the data into different models, we concluded that the mechanism of
release of Aceclofenac from the floating tablet was anomalous
diffusion transport and follows zero order kinetics, Stability
studies revealed that formulations were stable when stored at
different temperatures and the values were within permissible
limits. X ray imaging studies results showed that tablet was float
more than 8 h in gastric region of the Albino rabbits.
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