Contents:
1. The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future 2. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism 3. Sample Preparation 4. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis 5. Quantitative Mass Spectronomy 6. Immunoassay in Bioanalysis 7. Phase I Metabolism 8. Phase II Enzymes 9. In vitro Techniques for Investigating Metabolism 10. Drug to Drug Interactions: an in vitro Approach 11. Clinical Impact of Drug Interactions 12. PreClinical Pharmacokinetics 13. Pharmacokinetic / Pharmacodynamic Modelling in PreClinical Drug Discovery 14. Toxicokinetics 15. Protein Binding in PlasmaA Case History of a Highly Protein Bound Drug 16. Metabolite Identification by Spectroscopy 17. Whole Body Autoradiography 18. Radiolabelled Studies in Man 19. Molecular Biology

Pro ADO.NET Data Services: Working with RESTful Data is aimed at developers interested in taking advantage of the RESTstyle data services that ADO.NET Data Services (formerly codenamed Astoria) provides. The book shows how to incorporate ADO.NET Data Services into a wide range of common environments, including BizTalk, Ajax and Silverlight client applications. The material is intended for professional developers who are comfortable with the .NET 3.5 Framework but are coming to ADO.NET Data Services for the first time and want to understand how to integrate it into their own applications and enterprise solutions. The book is packed full with extensive realworld solutions and exercises, ensuring you walk away with a deep understanding of how to use ADO.NET Data Services to your best advantage.

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting - until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug-drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

Stress is the process in which environmental demands exceed an individuals ability to cope, resulting in affective, behavioural, and physiological changes. In response to stress, the body activates several pathways as the hypothalamic-pituitary-adrenal (HPA), sympathetic-adrenal-medullary, renin-angiotensin system (RAS) and parasympathetic system in attempting to preserve homeostasis. This book provides new research on the impact chronic stress has on overall health.

One of the cornerstones of Canadian culture, the National Film Board has throughout its history mirrored the social issues that preoccupy Canadians. Gary Evans traces the de- velopment of the postwar NFB, picking up the story where he left it at the end of his earlier work, John Grierson and the National Film Board: The Politics of Wartime Propaganda.

Evans points out that although Ottawa has not meddled in the operation of the NFB, outside stimuli have regularly forced the Film Board to reassess its mandate, a process which often has brought about as much confusion as light. For example, the unbridled optimism and expansion of the fifties and sixties led to English Production's desire for 'democratization' of programming, an end to the power of executive producers, and an expansion of the Film Board's core of permanent employees, all of which nearly caused the organization to founder. On the French side, despite the filmmakers' preference for the feature film rather than the cinema verite documentary, many in Ottawa regarded their 'political' films as both unfair attacks on the federal system and anachronisms coming from a federal institution. Throughout, the English-French tug of war so integral to the Canadian identity is a recurring theme.

Sources include interviews with former ministers, government film commissioners, policy-makers, and filmmakers, as well as archival documents and films. From them Evans has produced the first study to document the key trends in postwar Canadian filmmaking and to examine the role of film in the evolution of federal cultural policy.