The riveting true story of John and Aileen Crowley's race to find a cure for Pompe disease that inspired the movie Extraordinary Measures

With three beautiful children, a new house, and financial security, John and Aileen Crowley were on top of the world--until their two youngest children, fifteen-month-old Megan and five-month-old Patrick, were diagnosed with Pompe disease and given only months to live. Refusing to accept a death sentence, John quit his financial consultant job and invested his life savings in a biotechnology start-up to research the disease and find a cure. Battling scientific setbacks, conflict of interest accusations, and business troubles, John and Aileen would be tested to their limits as they valiantly fought, and succeeded, in finding revolutionary new treatment for the disease--offering hope to Megan, Patrick, and the many children and families affected by Pompe disease around the world.

The inspiration for the captivating film Extraordinary Measures, starring Brendan Fraser and Harrison Ford, The Cure is a remarkable true story of cutting-edge science, business acumen and daring, and one family's indomitable spirit.

In this engaging and easy text, the authors explore the foundational works of Hinduism. Spanning philosophy, mythology, poetry and music, this book is sure to educate, as well as entertain.

By applying data analytics techniques and machine learning algorithms to predict disease, medical practitioners can more accurately diagnose and treat patients. However, researchers face problems in identifying suitable algorithms for pre-processing, transformations, and the integration of clinical data in a single module, as well as seeking different ways to build and evaluate models. The Handbook of Research on Disease Prediction Through Data Analytics and Machine Learning is a pivotal reference source that explores the application of algorithms to making disease predictions through the identification of symptoms and information retrieval from images such as MRIs, ECGs, EEGs, etc. Highlighting a wide range of topics including clinical decision support systems, biomedical image analysis, and prediction models, this book is ideally designed for clinicians, physicians, programmers, computer engineers, IT specialists, data analysts, hospital administrators, researchers, academicians, and graduate and post-graduate students.

This lovely version of Srimad Bhagavatam is the labour of love of a grandmother for her grandaughters who live overseas, helping them develop a strong appreciation for the wonders of one of the most fundamental works of the ancients of India.

"A Daughter's Desire, A Mother's Worst Nightmare" tells the true story of one woman's quest as she struggles to preserve her arranged marriage by continuing in her abusive relationship. The names have been changed to protect the privacy of the people involved in the story. Shivani Ragunandan, a twenty-two-year-old college graduate, found herself betrothed into marriage by her family. Although it was not what she truly wanted, she went ahead with the wedding-only to find herself in a very unhappy marriage. Her husband was emotionally and physically abusive, cheating on her whenever the opportunity presented itself. Abiding by the rules of an arranged marriage in her Indo-Guyanese tradition, she was not allowed to file a divorce. She tried continuously to preserve her marriage to her twenty-seven-year-old husband. Although Shivani knew deep inside that this was not what she wanted, she feared her innocence, dignity, and reputation would be tarnished forever if she left her husband. Bound by cultural ties, she had no one to turn to but the celestial deities and her mother for guidance, faith, and strength.

Many new social and economic organizations are emerging in different parts of Asia Pacific which have skillfully adapted western capitalism to suit their own specific requirements. They have also put to effective use their own social and cultural values to get the best economic results. Japan used its heritage of associated living to overcome adversarial labour and management relations; Singapore made use of Confucial emphasis on social discipline and respect for merit to build a meritocratic society; Indonesia used its genius for eclecticism to build its own brand of social pragmatism, and then used it for economic growth; Thailand used the concept of merit in Theravada Buddhism to accelerate economic growth; and Malaysia used its own growing pragmatism to balance conflicting ethnic demands. The book examines the variety of address their respective core development issues and simultaneously register an explosive economic growth.

In 21st-century America, one of the goals of the education is to successfully prepare students for their meaningful, sustained, and robust participation in a democratic society. In the context of K-12 science education, this means educating students so that they develop into future adult citizen capable of considering and deciding on conflicting issues and policies influenced by science, technology, and sustainability issues. The challenge for science education is thus to find successful ways to integrate content, pedagogy, and citizenship education. It is important to examine curricular approaches in science classrooms since most of the science education a student receives take place in the context of a formal school science curriculum. Most curricular materials in science education allow students to engage in what is commonly referred to as an inform, verify, practice (IVF) format. Using this format, students gain access to information either through a lecture or a text, attempt to verify the presented information through lab activities, and may practice the mastered information with questions and/or problems. These curricular approaches do not explicitly integrate citizenship education to facilitate students' understandings of issues and policies shaped by science, technology, and sustainability issues. In order to bridge this gap, curricula guided by sociocultural perspectives may be a possible answer. Existing literature integrating sociocultural perspectives in the school science curriculum include context-based science, connected science, contextualized science, and/or socioscientific issues (SSI). These curricular approaches are being examined to document their effectiveness by linking social dilemmas with conceptual or technological links to science. This study integrates science education reform documents, blends sociocultural theoretical frameworks, and draws upon empirical data to contribute to the use of sociocultural theory in science education in an urban middle school setting. Current findings indicate that urban children are not experiencing much success when it comes to school science. Traditional paradigms for science education research focus on the learning of science using IVF format with little regard for the sociocultural context. In this book, the author posits that the exploration of urban students' engagement with school science using sociocultural perspectives may uncover factors that influence students learning and success in the science classrooms. The author further proposes that using curricula framed around sociocultural perspectives may develop students' understandings about the role science and technology plays in their lives, as well as well as in the larger society, thus making science more accessible and relevant for these children in urban settings. There has been no study to date that examines the impact of curricular approaches guided by a sociocultural framework (contextualized curriculum in this study) on the comprehension level and attitudes of students. The study fills that gap and holds implications for the inclusion of alternative curricular framework in urban middle school science classrooms. The author has used a mixed-methods study and draws upon both quantitative and qualitative data sources. The study design allows the reader to appreciate the perspectives of participating students and teachers on the use of contextualized curricular framework versus curricular framework guided by IVF practices in urban middle school science classrooms. This is an important book for collections in education, particularly science and K-12.

This book explores the universal and highly topical issues of ageing and retirement. It places a particular focus on the macroeconomic aspects of the ageing and retirement of college and university teachers, through a case study of teachers and professors in France and India. While the ageing of the population and the financing of the pension system are notoriously pressing issues in Western nations such as France, it has previously not been acknowledged that these issues are also critical to the development trajectory of emerging countries such as India. The book also highlights the importance of pensions for welfare, well-being and stability in all categories of workers, including workers in the informal sector and private companies devoid of pension schemes, where jobs are largely irregular and temporary in nature. It will be of great interest to researchers in the fields of comparative education, sociology and economics.

This book explores the significant role education plays in the promotion of human development and gender equality in India, situating this progression in relation to developed nations, the other BRIC countries and the ongoing attainment of the Millennium Development Goals.

This book provides an empirically formulated foundation for conflict-sensitive conservation, a field in which the existing literature relies primarily on anecdotal evidence. Seeking to better understand the impact of conflict on the implementation and outcomes of environmental projects, the Global Environment Facility (GEF) Independent Evaluation Office and the Environmental Law Institute undertook an evaluation of GEF support to fragile and conflict-affected contexts. Following a qualitative and quantitative analysis of documents from more than 4000 projects, the research team discovered a statistically significant negative correlation between a country’s Fragile States Index score and the implementation quality of environmental projects in that country. In this book, the evaluation and research team explain these groundbreaking findings in detail, highlighting seven key case studies: Afghanistan, Albertine Rift, Balkans, Cambodia, Colombia, Lebanon and Mali. Drawing upon additional research and interviews with GEF project implementation staff, the volume illustrates the pathways through which conflict and fragility frequently impact environmental projects. It also examines how practitioners and sponsoring institutions can plan and implement their projects to avoid or mitigate these issues and find opportunities to promote peacebuilding through their environmental interventions. Examining data from 164 countries and territories, this innovative book will be of great interest to students and scholars of environmental management, conservation, international development and the fast-growing field of environmental peacebuilding. It will also be a great resource for practitioners working in these important fields.

With an annual growth rate of over 35%, wind is the fastest growing energy source in the world today. As a result of intensive research and developmental efforts, the technology of generating energy from wind has significantly changed during the past five years. The book brings together all the latest aspects of wind energy conversion technology - right from the wind resource analysis to grid integration of the wind generated electricity. The chapters are contributed by academic and industrial experts having vast experience in these areas. Each chapter begins with an introduction explaining the current status of the technology and proceeds further to the advanced lever to cater for the needs of readers from different subject backgrounds. Extensive bibliography/references appended to each chapter give further guidance to the interested readers.

The book offers insight into the healthcare system by exploring emerging technologies and AI-based applications and implementation strategies. It includes current developments for future directions as well as covering the concept of the healthcare system along with its ecosystem. Data-Centric AI Solutions and Emerging Technologies in the Healthcare Ecosystem focuses on the mechanisms of proposing and incorporating solutions along with architectural concepts, design principles, smart solutions, decision-making process, and intelligent predictions. It offers state-of-the-art approaches for overall innovations, developments, and implementation of the smart healthcare ecosystem and highlights medical signal and image processing algorithms, healthcare-based computer vision systems, and discusses explainable AI (XAI) techniques for healthcare. This book will be useful to researchers involved in AI, IoT, Data, and emerging technologies in the medical industry. It is also suitable as supporting material for undergraduate and graduate-level courses in related engineering disciplines.

This book includes basics of impedance spectroscopy technology, substrate compatibility issues, integration capabilities, and several applications in detection of different analytes. It helps explore the importance of this technique in biological detection, related micro/nano-fabricated platforms and respective integration, biological synthesis schemes to carry out the detection, associated challenges, and related future directions. The various qualitative/quantitative findings of several modules are summarized in the form of the detailed descriptions, schematics, and tables. Features: Serves as a single source for exploring underlying fundamental principles and the various biological applications through impedance spectroscopy. Includes chapters based on non-biological applications of impedance spectroscopy and IoT enabled impedance spectroscopy-based methods for detection. Discusses derivations, substrates, applications, and several integrations. Describes micro/nanofabrication of impedance-based biological sensors. Reviews updated integrations like digital manufacturing and IoT. This book is aimed at researchers and graduate students in material science, impedance spectroscopy and biosensing.

Real-world issues can be translated into the language and concepts of mathematics with the use of mathematical models. This book provides these real-world examples, explores research challenges in numerical treatment, and demonstrates how to create new numerical methods for resolving problems. Theories and practical applications in the sciences and engineering are also discussed. Students of engineering and applied mathematics, as well as researchers and engineers who use computers to solve problems numerically or oversee those who do, will find this book focusing on advance numerical techniques to solve linear and nonlinear differential equations useful. Models guided by differential equations with intuitive solutions can be used throughout engineering and the sciences. Almost any changing system may be described by a set of differential equations. They may be found just about anywhere you look in fields including physics, engineering, economics, sociology, biology, business, healthcare, etc. The nature of these equations has been investigated by several mathematicians over the course of hundreds of years and, consequently, numerous effective methods for solving them have been created. It is often impractical to find a purely analytical solution to a system described by a differential equation because either the system itself is too complex or the system being described is too vast. Numerical approaches and computer simulations are especially helpful in such systems.

This book provides an empirically formulated foundation for conflict-sensitive conservation, a field in which the existing literature relies primarily on anecdotal evidence. Seeking to better understand the impact of conflict on the implementation and outcomes of environmental projects, the Global Environment Facility (GEF) Independent Evaluation Office and the Environmental Law Institute undertook an evaluation of GEF support to fragile and conflict-affected contexts. Following a qualitative and quantitative analysis of documents from more than 4000 projects, the research team discovered a statistically significant negative correlation between a country’s Fragile States Index score and the implementation quality of environmental projects in that country. In this book, the evaluation and research team explain these groundbreaking findings in detail, highlighting seven key case studies: Afghanistan, Albertine Rift, Balkans, Cambodia, Colombia, Lebanon and Mali. Drawing upon additional research and interviews with GEF project implementation staff, the volume illustrates the pathways through which conflict and fragility frequently impact environmental projects. It also examines how practitioners and sponsoring institutions can plan and implement their projects to avoid or mitigate these issues and find opportunities to promote peacebuilding through their environmental interventions. Examining data from 164 countries and territories, this innovative book will be of great interest to students and scholars of environmental management, conservation, international development and the fast-growing field of environmental peacebuilding. It will also be a great resource for practitioners working in these important fields.

This volume fills a major gap in the evidence base on adolescents and youth in India by bringing together research, policy critiques and programme analyses in an intersectoral and multidisciplinary way. With about 373 million persons between the ages of 10 and 24 years, India has the largest number of young people of any country in the world. While this large cohort presents an excellent opportunity to reap a rich demographic dividend, their potential can be realised only with intelligent investments, which create well nourished, healthy, appropriately educated and skilled youth. This volume is based on desk reviews and is complemented by discussions with experts in 4 key thematic areas: nutrition, sexual and reproductive health, mental health and livelihoods, overall focusing on the health and wellbeing of the young in India. Each chapter provides a comprehensive picture of the current situation in a focal theme and identifies significant gaps in information/data and programmes. In addition, it explores the scenario of building capacity for undertaking research on, and with adolescents, through a qualitative needs assessment. This timely volume provides a thorough overview of related research, policy and programmes for a wide group of social and behavioural scientists and public health experts interested in India's young people.