Focussing on end-of-life care for people who use, or have used, substances, this book explores their social and health care needs and the multiple disadvantages they have often experienced, discussing the complexities around access to care that result. Presenting models of good practice, case studies and empirically based evidence, Substance Use, End-of-Life Care is informative, rigorous and useful for policy and practice development. The first section foregrounds the personal experiences of people living with substance use, their families and friends, and the health and social care professionals who work with them. The second section looks at how health inequalities can impact people in need of palliative care, including chapters on health literacy, mental health and learning disabilities. The final section explores social challenges that may be experienced, including homelessness, sex work, racism and incarceration. This interdisciplinary volume is essential for researchers, practitioners, students and educators working around substance use, mental health and palliative and end-of-life care, who are looking for guidance and a reference for their work in supporting people at the end of their lives who have multiple and often complex needs.