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This is the first book to provide a broad framework for obtaining
an in depth understanding of the state-of-the-art knowledge on
abnormalities of non-coding RNAs found to be associated with
colorectal cancer pathogenesis. Readers will discover possible
mechanisms underlying the substantial roles played by non-coding
RNAs in molecular hallmarks of colorectal cancer. This work further
provides the comprehensive overview and novel insights into using
of non-coding RNAs as colorectal cancer biomarkers enabling early
detection of the disease, prognostic stratification of the patients
and prediction of therapeutic response. The reader is introduced to
the overview of modern non-coding RNAs-based therapeutic
strategies, and summary of their preclinical testing performed in
colorectal cancer. The work is written for researchers who want to
explore current state of the knowledge in this interesting field of
molecular oncology.
This is the first book to provide a broad framework for obtaining
an in depth understanding of the state-of-the-art knowledge on
abnormalities of non-coding RNAs found to be associated with
colorectal cancer pathogenesis. Readers will discover possible
mechanisms underlying the substantial roles played by non-coding
RNAs in molecular hallmarks of colorectal cancer. This work further
provides the comprehensive overview and novel insights into using
of non-coding RNAs as colorectal cancer biomarkers enabling early
detection of the disease, prognostic stratification of the patients
and prediction of therapeutic response. The reader is introduced to
the overview of modern non-coding RNAs-based therapeutic
strategies, and summary of their preclinical testing performed in
colorectal cancer. The work is written for researchers who want to
explore current state of the knowledge in this interesting field of
molecular oncology.
MicroRNA in Human Malignancies offers a deep overview of the role
and translational significance of miRNAs in the development of
cancer and other malignancies. The book establishes the foundations
of the field by covering essential mechanisms and the translational
potential of miRNAs in the field of oncology. Specific topics
covered include invasion and metastasis, miRNAs and metabolism, and
opportunities of miRNAs in therapeutics. Chapters on diseases
include content on disease-related pathophysiology, as well as
diagnostic, prognostic and predictive value. This book is an
essential reference for students entering the field, as well as
researchers and investigators.
From pathology to treatment, MicroRNAs in Diseases and Disorders
highlights the role of microRNAs (miRNAs) in the development and
progression of a variety of diseases, including cancer,
neurological disease, endocrine disease and autoimmune disease, and
underscores the utilization of miRNA targets in the treatment of
these conditions. Providing a comprehensive account, this book also
includes the identification of miRNAs as diagnostic and prognostic
biomarkers for disease, as well as evaluates translational value
from clinical trials using synthesized and functionalized miRNA
mimics and inhibitors. With a global contribution list and chapters
from leading experts across the field, MicroRNAs in Diseases and
Disorders is an invaluable reference to miRNA researchers and
health professionals in a variety of disease areas in government,
academia and industry. The book will also appeal to pharmaceutical
and medicinal chemists with an interest in miRNA targeting
therapeutics, as well as to advanced students in chemical biology
and drug discovery.
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