The contemporary management of patients with cancers of the head and neck is under careful scrutiny and major changes are being introduced in order to improve the potenti al not only for long-term control but also for less in the way of disfiguring and distres sing complications associated with the treatment programs. In 1988, the American Cancer Society estimates that there will be 42400 new cases of malignant tumors of the head and neck diagnosed with 12 850 deaths. In general, the prognosis for patients with malignant tumors of the head and neck re gion depends upon the site of origin, the local and regional extent of the tumor, the Kar nofsky status of the patient as well as the patient's general medical condition. The poten tial for cure for early stage tumors is extremely high particularly for those lesions involving the vocal cord, oral cavity, and the anterior two-thirds of the tongue. Major advances have been made in the management of head and neck cancer by the innovative utilization of surgery with radiation therapy. Small tumors can be cured by ei ther surgery or radiation therapy with equally good results. However, far advanced tu mors are more complicated and more difficult to cure requiring combined, integrated, multimodal programs of management. Therefore, the previously general poor prognosis for advanced tumors is becoming better with more aggressive treatment regimens."

Jack Olivetti, and his protege, Meredith Jones, have discovered a new treatment process incorporating a combination of laboratory measurements and computer modeling. The treatment is individualized for each patient. The Dean of the Medical School and his associates in a local BioTech Company, AVARTEC, want to discredit the discovery and take it over themselves. Meredith's grandmother develops ovarian cancer, which forces the investigators to cut corners in moving their discovery into clinical trials. The CEO of AVARTEC sabotages the clinical trial allowing several patients to die in the process. To keep this from getting out, the CEO hires professional killers to eliminate Jack and Meredith culminating in a chase through the otherwise deserted AVARTEC laboratories.