This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives. The Clinical Evaluation of a Food Additive: Assessment of Aspartame begins by describing the nuts and bolts of food additive safety evaluation in humans, including an insightful historical perspective of the development of good clinical practice guidelines. It provides the regulatory requirements for human research, as well as key elements for the design and conduct of human studies. The scientific and regulatory considerations of food additive safety are explored, including interesting descriptions of aspartame's key animal safety studies. In addition, the book reviews the medical postmarketing surveillance system developed for identifying and evaluating reports of aspartame's alleged adverse health effects. Through meticulous research and systematic clarity, The Clinical Evaluation of a Food Additive: Assessment of Aspartame provides work-saving, state-of-the-art examples to guide future testing and evaluation of tomorrow's food additives.

Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors.
Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental factors impact the progression of genetic and cellular changes in common forms of cancer. This broad concept can now be investigated within a basic and clinical research context for specific types of cancer. This book attempts to cover the current available knowledge in this new field of nutritional oncology written by invited experts. This book attempts to provide not only the theoretical and research basis for nutritional oncology, but will offer the medical oncologist and other members of multidisciplinary groups treating cancer patients practical information on nutrition assessment and nutritional regimens, including micronutrient and phytochemical supplementation. The editors hope that this volume will stimulate increased research, education and patient application of the principles of nutritional oncology.
NEW TO THIS EDITION:
* Covers hot new topics of nutrigenomics and nutrigenetics in cancer cell growth
* Includes new chapters on metabolic networks in cancer cell growth, nutrigenetics and nutrigenomics
* Presents substantially revised chapters on breast cancer and nutrition, prostate cancer and nutrition, and colon cancer and nutrition
* Includes new illustrations throughout the text, especially in the breast cancer chapter
* Includes integrated insights into the unanswered questions and clearly defined objectives of research in nutritional oncology
* Offers practical guidelines for clinicians advising malnourished cancer patients and cancer survivors on diet, nutrition, and lifestyle
* Provides information on the role of bioactive substances, dietary supplements, phytochemicals and botanicals in cancer prevention and treatment

This volume explores basic and advanced aspects of our understanding of and current treatment for obesity. Contributors provide a multidisciplinary overview of this disease and offer practical guidance on state-of-the-art methods of assessment and treatment.;The first section of the book examines the disease of obesity and its metabolic consequences. It explores obesity in relation to physiological and psychological health, and describes the clinical aspects of properly evaluating obese patients. The roles of dietary factors, appetite, exercise, metabolism, and the endocrine system in obesity are discussed, as well as the effects of significant weight loss on long-term health. The psychology of obesity weight loss, and regain is also discussed.;The second section provides practitioners with detailed guidelines for selecting and implementing multidisciplinary treatment that incorporates dietary intervention, exercise, behaviour modification, and stress management, and, when necessary, surgery or pharmacotherapy. Matching patients with clinical interventions and treatment settings is emphasized, and strategies for maintaining weight loss are presented.;The final chapter illustrates how to design interventions appropriate for the hospital, physician's office, clinic, home, and workplace, and how to integrate different types of interventions in multiple settings.;Physicians, dietitians, psychiatrists, psychologists, exercise physiologists, and allied health professionals, as well as obesity researchers, should gain a broader understanding of the evaluation and treatment of obesity from this volume.