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The deregulation of dietary supplements and natural products
marketing by the FDA has widened the natural products market in
Europe and worldwide. While the discussion about the validity of
the plant approach to nutrition and diseases treatment continues,
the explosion of the use of whatever is considered "natural" has
generated concern about effectiveness and danger. Incorporating
information ranging from regulatory aspects to clinical trial and
vigilance, Herbal Medicines: Development and Validation of
Plant-Derived Medicines for Human Health: Provides a reference
model for those who would like to start the R&D process for a
natural product Discusses fundamental issues in the development of
traditional medicines for the benefit of human health Takes a
sequential rational approach to the subject matter Brings awareness
to the many problems facing the development of medicinal herbal
products, such as quality control, pharmacokinetic, and
pharmacodynamic issues This book takes readers on a rational path
for development of efficacious medicinal herbal products. It points
out the many problems facing the development of these products,
such as quality control, pharmacokinetic, and pharmacodynamic
issues. It suggests areas where future developments should occur
given healthcare needs and public health considerations.
Recent clinical studies have demonstrated an impact of aromatherapy
on the control of symptoms associated with human diseases not fully
controlled by conventional therapy. Aromatherapy: Basic Mechanisms
and Evidence Based Clinical Use provides an up-to-date compilation
of background scientific information that advocates the application
of currently developed clinical studies on the effects of
aromatherapy to the treatment of human diseases such as mild,
stress-induced mood disorders, infectious diseases, and age-related
disturbances. The book encompasses all aspects of successful
clinical use of aromatherapy, including phytochemistry, technology,
and clinical trials. It outlines a rational basis for clinical
translation of aromatherapy for treating human diseases in need of
safer therapies. It also describes evidence-based use of
aromatherapy in controlling clinical manifestations of severe
diseases for which conventional therapies often fail, such as
managing agitation and aggression associated with Alzheimer's
disease and other neurodegenerative diseases. Containing a wealth
of references and a thorough presentation of knowledge on essential
oils and aromatherapy, this book is a valuable resource for
students, researchers, clinicians, and policy makers in health care
systems. It details the current clinical uses of aromatherapy while
promoting further clinical development in areas where therapy is
lacking.
The deregulation of dietary supplements and natural products
marketing by the FDA has widened the natural products market in
Europe and worldwide. While the discussion about the validity of
the plant approach to nutrition and diseases treatment continues,
the explosion of the use of whatever is considered "natural" has
generated concern about effectiveness and danger. Incorporating
information ranging from regulatory aspects to clinical trial and
vigilance, Herbal Medicines: Development and Validation of
Plant-Derived Medicines for Human Health: Provides a reference
model for those who would like to start the R&D process for a
natural product Discusses fundamental issues in the development of
traditional medicines for the benefit of human health Takes a
sequential rational approach to the subject matter Brings awareness
to the many problems facing the development of medicinal herbal
products, such as quality control, pharmacokinetic, and
pharmacodynamic issues This book takes readers on a rational path
for development of efficacious medicinal herbal products. It points
out the many problems facing the development of these products,
such as quality control, pharmacokinetic, and pharmacodynamic
issues. It suggests areas where future developments should occur
given healthcare needs and public health considerations.
This volume provides a broad overview of important new advances in
the field of Neuropharmacology. In 20 chapters, a selection of
international contributors discuss topics including endocannabinoid
function, pain, stress, astrocytes etc, and new possibilities for
treatments of neurological diseases with neuropharmacological
approaches.
- Cutting-edge articles in neuropharmacology
- Discusses new possibilities for treatments of neurological
disorders
- Very international authorship providing a global view of the
state of research
Neuroinflammation has been implicated recently in the pathogenesis
of many neurodegenerative diseases. The cross-talk between neurons
and non-neuronal cells seems to be a critical step in the
progression of neurodegeneration and molecules that have a
beneficial role may turn into harmful players. Thus, matrix
metalloproteinases (MMPs), which are involved in axonal growth and
regeneration as well as synaptic plasticity, may also have
detrimental effects. Recent evidence has linked MMPs to conditions
like ischemia, multiple sclerosis, Alzheimer's disease and
suggested that, together with their role in the degradation of
extracellular macromolecules, MMPs could work as important
signalling molecules from injured neurons to the microglia.
Thus, MMP-3 has been shown to induce the release of
pro-inflammatory cytokines from microglia via activation of ERK and
NF-kB-dependent pathways. Increasing evidence highlights the
importance of a balanced cross-talk between neurons and
non-neuronal cells and indicates that the presence of reactive
astrocytes, the activation of microglia and the release of
inflammatory mediators may contribute to the progression of many
central nervous system disorders, independently of the nature of
the primary pathogenic event. However, many aspects still remain
controversial and much more effort is needed to understand the role
of neuroinflammatory mediators and processes in these conditions.
This volume brings together renowned, international scientists to
discuss current knowledge and views on the mechanisms of
neuroinflammation, on its role in the context of different
neurodegenerative diseases (i.e. Alzheimer's, prion disease,
HIV-associated dementia, multiple sclerosis, pain) and on the
potential approaches for future therapeutic strategies.
Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the
latest release in the Progress in Brain Research series, highlights
new advances in the field, with this new volume presenting
interesting chapters written by an international board of authors.
Chapters in this volume include the Genetics of glaucoma,
Artificial intelligence and deep learning in glaucoma detection and
monitoring, The role of commensal microflora-induced T cells
responses in glaucoma neurodegeneration, Retinal cell death in
experimental glaucoma, Experimental and clinical evidence on the
neuroprotective properties of Citicoline in glaucoma, Glaucoma
neurodegeneration and myopia, Neuronal regeneration with
pluripotent stem cells in glaucoma, and more.
New Trends in Basic and Clinical Research of Glaucoma: A
Neurodegenerative Disease of the Visual System is the latest volume
from Progress in Brain Research focusing on new trends in basic and
clinical research of glaucoma. This established international
series examines major areas of basic and clinical research within
neuroscience, as well as emerging subfields.
New Trends in Basic and Clinical Research of Glaucoma: A
Neurodegenerative Disease of the Visual System - Part B is the
latest volume from Progress in Brain Research focusing on new
trends in basic and clinical research of glaucoma. This established
international series examines major areas of basic and clinical
research within neuroscience, as well as emerging subfields.
Glaucoma is one of the main causes of blindness throughout the
world. It is characterized by death of the retinal ganglion cells,
which is associated with loss of the axons making up the optic
nerve. Recent studies have demonstrated support for the
classification of glaucoma as a degenerative disease of the central
nervous system (CNS). The search for treatment modalities that are
effective for all patients with glaucoma has resulted in numerous
studies aimed at identifying neuroprotection strategies for the
treatment of this disease, like those used for other degenerative
diseases of the CNS.
The present book will provide an in-depth examination of the most
recent findings regarding glaucoma, including risk factors,
diagnosis, clinical monitoring, treatment, and above all, the need
for treatment based on the concept of neuroprotection. A large part
of the book is devoted to research related to this new approach to
the treatment of glaucoma. Aspects that will be analyzed include
experimental models of glaucoma, clinical protocols for the study
of neuroprotective therapies, mechanisms underlying glaucomatous
damage to neurons of the retina and other "stations" in the visual
pathways of the CNS, and finally proposals for new strategies for
preventing neuronal injury in glaucoma patients.
* Describes the most recent developments on neuroprotection of the
optic nerve, including experimental models now used and clinical
protocols
* Discusses new strategies for the prevention of neuronal injury in
glaucoma patients
* Focuses on evidence-based risk factors, innovative diagnostic
aspects and advanced medical/surgical treatment of glaucoma
Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part
B, Volume 257, the latest release in the Progress in Brain Research
series, highlights new advances in the field, with this new volume
presenting interesting chapters written by an international board
of authors. Topics covered in this new release include Glaucoma
neurodegeneration and myopia, Links between obstructive sleep apnea
and glaucoma neurodegeneration, Artificial intelligence and deep
learning in glaucoma: Current state and future prospects, Brain
networks reorganization and functional disability in glaucoma,
Advanced vascular examinations of the retina and optic nerve head
in glaucoma, and much more.
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