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It was at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded
his famous "site-chain theory" -which described the basic
immunological principal of antibody-antigen interactio- on the
occasion of the opening of the Institute for Experimental
Therapeutics (which was later named after him). Nearly 100 years
have passed since, and in retrospect it can be said that the
"Ehrlich Era" (first steps in immunology "Magic Bullet" concept)
and the "Behring Era" (detection of antibodies and serum therapy)
formed the essential basis in the development of immunology. Niels
K. Jerne, the former director of the Paul Ehrlich Institute in
Frankfurt/Main received, together with Georges Kohler and Cesar
Milstein, the Nobel Prize in Medicine 1984. These late successors
of Ehrlich and Behring first described the hybridoma technology (in
1975) which enabled one of the most important and revolutionary
technological innovations in the field of immunology -the
production of monoclonal antibodies. It happens that, the time of
the publication of this book, just a decade has passed since the
first use of radiolabelled monoclonal antibodies in man (by the
Lausanne Group). Over these 10 years a tremendous progress has
taken place in the field of immunoscintigraphy: A large panel of
highly specific monoclonal antibodies against tumour-associated
antigens as well as normal cell compounds have been developed.
Enormous progress has been made in the field of radiolabelling
-from iodine-131 to technetium-99mor even
positron-emittingradionuclides, e. g. iodine-124.
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