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The cholinergic system has been recognized as playing an important
role not only in several forms of dementia besides Alzheimer's
Disease, but also in other CNS degenerative and psychiatric
disorders. Following on from the success of two previous
publications in the cholinergic field - Cholinesterases and Their
Inhibitors and Butyrylcholinesterase: Its Function and Inhibitors -
Doctor Ezio Giacobini and Professor Giancarlo Pepeu have prepared
this comprehensive and timely volume, which will be useful to both
clinical and pre-clinical specialists including neurologists,
psychiatrists, neuropsychologists, neuropharmacologists and
neurophysiologists, molecular neurobiologists and neurobiologists
in general.
Proceedings of the Fifth International Colloquium on Lecithin, held
in Cannes, France, April 10-12, 1989
Every three years early Spring witnesses the convening of a small
group of neuroscientists from many parts of the world. They are
devoted to the study of acetylcholine, the oldest of the known
neurotransmitters. To assess the level of knowledge, to take stock
of the still unsolved problems, to evaluate the practical meaning
of their findings, the cholinologists first met in 1969 in the
eerie atmosphere of a snow-covered Swedish forest, the second in
the Swiss Alps, the third facing the surf and foam of the Paci fic
waves. Finally in March 1980 Florence, her trees burgeoning in the
mild rain of March, confronted them with the temptation of her
monuments and museums. But the cholinologists bravely dismis sed
the temptations and went on with the presentations and discus sions
of the many papers which form the present book. The papers describe
the most recent development of investiga tions on acetylcholine.
They open with an extensive coverage of the developmental and
phylogenetic aspects of the cholinergic neurons. The regulation of
acetylcholine synthesis, release, post synaptic, electrical and
trophic effects in the peripheral chol inergic synapses including
ganglia, neuromuscular junction, myen theric plexus and heart is
then covered. Special emphasis is given to the cholinergic
mechanisms in the eye."
Widening the focus of the earlier colloquia in the series on
lecithin, 30 papers examine the properties, biochemistry, and
biological actions of individual phospholipids, dealing with
general aspects of phospholipid technology, terminology, and
analysis, and such specific topics as the pathogenetic
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