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In the last decade, genetics has been emerging as a primary issue
in the diagnosis and management of cardiomyopathies. This book is
intended to be a state-of-the-art monograph on these diseases,
describing their genetic causes, defining the molecular basis and
presenting extensive descriptions of genotype-phenotype
correlations. Other chapters are focused on the role of clinical
observation, on ECG and echocardiography. With its highlight on the
most recent discoveries in the field of molecular genetics as well
as on the correct clinical approach to patients with heart muscle
disease, the book is aimed at physicians and clinical cardiologists
with a particular interest in myocardial diseases and in their
genetic causes.
This book describes the role of basic and advanced imaging
techniques in the diagnosis of different types of cardiomyopathy,
including dilated cardiomyopathy, hypertrophic cardiomyopathy,
restrictive cardiomyopathy, arrhythmogenic right ventricular
cardiomyopathy and infiltrative/storage cardiomyopathies. While the
main focus is on echocardiography, the applications of cardiac
magnetic resonance imaging and computed tomography are also
described. Throughout, a clinically oriented approach is employed:
detailed attention is paid to differential diagnosis and numerous
high-quality images depict the main features of the various types
of cardiomyopathy. Consideration is also given to the genetics of
cardiomyopathies, with analysis of genotype-phenotype
relationships. Finally, the potential value of imaging in
prognostic assessment and in guiding treatment is described.
In the last decade, genetics has been emerging as a primary issue
in the diagnosis and management of cardiomyopathies. This book is
intended to be a state-of-the-art monograph on these diseases,
describing their genetic causes, defining the molecular basis and
presenting extensive descriptions of genotype-phenotype
correlations. Other chapters are focused on the role of clinical
observation, on ECG and echocardiography. With its highlight on the
most recent discoveries in the field of molecular genetics as well
as on the correct clinical approach to patients with heart muscle
disease, the book is aimed at physicians and clinical cardiologists
with a particular interest in myocardial diseases and in their
genetic causes.
This open access book presents a comprehensive overview of dilated
cardiomyopathy, providing readers with practical guidelines for its
clinical management. The first part of the book analyzes in detail
the disease's pathophysiology, its diagnostic work up as well as
the prognostic stratification, and illustrates the role of genetics
and gene-environment interaction. The second part presents current
and future treatment options, highlighting the importance of
long-term and individualized treatments and follow-up. Furthermore,
it discusses open issues, such as the apparent healing phenomenon,
the early prognosis of arrhythmic events or the use of genetic
testing in clinical practice. Offering a multidisciplinary approach
for optimizing the clinical management of DCM, this book is an
invaluable aid not only for the clinical cardiologists, but for all
physicians involved in the care of this challenging disease.
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