This book constitutes the thoroughly refereed post-conference proceedings of the 4th International Conference on Higher Education Learning Methodologies and Technologies Online, HELMeTO 2022, held in Palermo, Italy, in September 2022.  The 59 revised papers presented were carefully reviewed and selected from a total of 126 submissions. The papers present recent research on challenges of implementing emerging technology solution for online, online learning pedagogical frameworks, online learning technologies in practice, online learning strategies and resources, etc.