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Fanconi Anemia (FA), a rare genetic disease featuring excess cancer
risk and chromosomal instability, has received growing interest
after the discovery that one of the defective genes in FA is
associated with high-impact diseases such as familial breast cancer
and ovary cancers. A well-documented relationship has accumulated
in several decades and up to recently, studies have linked FA with
a redox imbalance (oxidative stress, OS) in FA cells. The toxicity
mechanisms of crosslinking agents (mitomycin C and diepoxybutane)
in FA cells, along with the roles of OS-related aldehydes and
glutathione in FA and in other diseases, are critically discussed.
Also discussed is the proinflammatory state in FA phenotype.
Additionally, recent studies have discovered an impairment in the
structure and function of mitochondria in FA cell lines, while
mitochondrial dysfunction in FA patients has so far been an
unexplored field warranting ad hoc investigations. This book
provides the readers with up-to-date information and perspectives
on Fanconi anemia and oxidative stress that may prompt further
elucidation of this intriguing disease, along with working
hypotheses in clinical research and patients' management.
This book presents the multifaceted aspects of rare earth elements
(REEs), focusing on both their potential benefits and adverse
health effects. The adverse impacts of REEs on human and
environmental health raise a growing concern not only in the
scientific community but also among a number of stakeholders,
potentially including students, media workers, and decision makers.
The recognized and potential benefits arising from REE-related
technological applications may envisage their further advantages. A
limited number of books have been devoted so far to REEs, and they
mainly focus on REE-related chemistry, mineralogy, economy, and
developing technologies for these elements. This book presents
recent research achievements in REE-associated health effects,
which have been mostly confined to journal reports on individual
laboratory studies so far. It is an updated and balanced approach
to REE research and technology. It provides novel yet established
information as stated in the title "At the Crossroads between
Toxicity and Safety," with particular emphasis on the hormesis
phenomenon.
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